PINK1

Serine/threonine-protein kinase PINK1, mitochondrial · Q9BXM7 · PINK1 on Sugi Atlas →

0 patent compounds predicted against PINK1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to PINK1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients PHASE4UNKNOWN
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R PHASE4WITHDRAWN
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy PHASE3RECRUITING
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
N-Acetylcysteine for Neuroprotection in Parkinson's Disease PHASE1/PHASE2COMPLETED
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study PHASE1UNKNOWN
Longitudinal Natural History Protocol for PRKN- and PINK1-Linked PD nanNOT_YET_RECRUITING
Effect of Ketone Esters in Parkinson's Disease nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort nanRECRUITING
Cell Studies of Parkinson's Disease nanCOMPLETED
Autologous Mitochondrial Transplant for Cerebral Ischemia nanRECRUITING
Fox BioNet Project: LRRK2-002 nanCOMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED
Mitophagy and Mitochondrial DNA Dynamics During Ramadan Dry Fasting vs 16:8 Time-Restricted Feeding nanNOT_YET_RECRUITING
Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation nanUNKNOWN
Optimistic and Pessimistic Dopamine Signals in the Human Brain: a Mapping and Modelling Study in Health and Parkinson's Disease nanRECRUITING
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure? nanRECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Rostock International Parkinson's Disease Study (ROPAD) nanCOMPLETED
Exercise Neuroprotection in Parkinson's Disease nanRECRUITING
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML) nanCOMPLETED
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure nanRECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Biological Markers in Parkinson's Disease nanCOMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING
LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PINK1 binder may also engage these)

ProteinNameSimilarity
Q99MQ3 1.000 Q99MQ3 →
B5DFG1 0.999 B5DFG1 →
Q400G9 0.983 Q400G9 →
MAP3K6 Mitogen-activated protein kinase kinase kinase 6 0.983 landscape →
Q8C0R7 0.983 Q8C0R7 →
Q3U5Q7 0.981 Q3U5Q7 →
Q8BXP5 0.981 Q8BXP5 →
Q96F46 0.981 Q96F46 →
A4QNA8 0.980 A4QNA8 →
Q9WTR2 0.980 Q9WTR2 →
Q9Z2E3 0.979 Q9Z2E3 →
Q96MK2 0.979 Q96MK2 →
ERN2 Serine/threonine-protein kinase/endoribonuclease IRE2 0.979 landscape →
TELO2 Telomere length regulation protein TEL2 homolog 0.979 landscape →
B5DFA1 0.979 B5DFA1 →
Q5F479 0.978 Q5F479 →
RNF31 E3 ubiquitin-protein ligase RNF31 0.978 landscape →
Q924T7 0.978 Q924T7 →
Q8BM55 0.978 Q8BM55 →
Q8JZL1 0.978 Q8JZL1 →
F1MLB4 0.978 F1MLB4 →
P59240 0.978 P59240 →
Q7Z465 0.978 Q7Z465 →
Q8C2E4 0.978 Q8C2E4 →
Q8N309 0.978 Q8N309 →
Q6ZW76 0.978 Q6ZW76 →
Q95K25 0.978 Q95K25 →
D3ZND0 0.978 D3ZND0 →
Q9WTN3 0.978 Q9WTN3 →
Q8N9W5 0.978 Q8N9W5 →