RNF31

E3 ubiquitin-protein ligase RNF31 · Q96EP0 · RNF31 on Sugi Atlas →

63 patent compounds predicted against RNF31, 47 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Gliotoxin (SCHEMBL54420)	1.00	1/20
Gliotoxin (SCHEMBL4294337)	1.00	1/20
Gliotoxin (SCHEMBL9667270)	1.00	1/20
Gliotoxin (SCHEMBL12018743)	1.00	1/20
Gliotoxin (SCHEMBL12149513)	1.00	1/20
Gliotoxin (SCHEMBL12618354)	1.00	1/20
Gliotoxin (SCHEMBL13341245)	1.00	1/20
Gliotoxin (SCHEMBL14514067)	1.00	1/20
Gliotoxin (SCHEMBL14579856)	1.00	1/20
Gliotoxin (SCHEMBL14986985)	1.00	1/20
Gliotoxin (SCHEMBL20199940)	1.00	1/20
Gliotoxin G (SCHEMBL30567451)	0.88	1/20
SCHEMBL12901998	0.84	1/20
SCHEMBL14021819	0.84	1/20
SCHEMBL25722212	0.82	1/20
Gliotoxin (SCHEMBL6934245)	0.73	1/20
Gliotoxin (SCHEMBL4735750)	0.71	1/20
Gliotoxin (SCHEMBL14332623)	0.71	1/20
SCHEMBL18652980	0.66	1/20
SCHEMBL17971336	0.64	1/20

Clinical trials — most relevant to RNF31 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma	PHASE2	WITHDRAWN
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma	PHASE2	SUSPENDED
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Novel Molecular Targets and Innovative Therapeutic Perspective in Medulloblastoma	EARLY_PHASE1	RECRUITING
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome	nan	RECRUITING
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1	nan	RECRUITING
Implication of Genetic Variations in Long Intergenic Non-coding RNA 00511 (LINC00511) in Colorectal Cancer	nan	COMPLETED
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
Identification of an Asthma Susceptibility Gene on 3P	nan	COMPLETED
Novel Urine-Based DNA Methylation Biomarkers for Urothelial Bladder Carcinoma Detection in Patients With Hematuria	nan	COMPLETED
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome	nan	RECRUITING
DNA Repair Genes and Outcomes in Patients With Stage III NSCLC	nan	UNKNOWN
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Next-Generation Sequencing-based Germline and Somatic Genetic Testing in Triple-negative Breast Cancer	nan	UNKNOWN
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Clinical Studies of Endometrial Cytology and Cervical Methylation Assays in Endometrial Cancer Screening and Fertility-Preservation Evaluation	nan	NOT_YET_RECRUITING
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions	nan	COMPLETED
LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients	nan	ACTIVE_NOT_RECRUITING
Transcripts with Retained H/ACA Box SnoRNA Sequences As Biomarkers for Estrogen Dependence in Lum-B Breast Carcinomas	nan	ACTIVE_NOT_RECRUITING
Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders	nan	RECRUITING
Genes and Other Risk Factors for Second Primary Breast Cancer in Women With Breast Cancer and Their Female Family Members and Friends	nan	UNKNOWN
Genes Contributing to Hereditary Ovarian Cancer in Women and BRCA1/2 Wildtype Families	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RNF31 binder may also engage these)

Protein	Name	Similarity
Q924T7	—	1.000	Q924T7 →
E6ZIJ1	—	0.988	E6ZIJ1 →
Q9BST9	—	0.984	Q9BST9 →
Q9Y613	—	0.984	Q9Y613 →
CDC42BPG	Serine/threonine-protein kinase MRCK gamma	0.984	landscape →
Q7T0L4	—	0.983	Q7T0L4 →
Q66H85	—	0.983	Q66H85 →
Q9UJY4	—	0.983	Q9UJY4 →
TELO2	Telomere length regulation protein TEL2 homolog	0.983	landscape →
Q58CQ5	—	0.983	Q58CQ5 →
MAP3K6	Mitogen-activated protein kinase kinase kinase 6	0.982	landscape →
Q8C6B2	—	0.982	Q8C6B2 →
B5DFA1	—	0.982	B5DFA1 →
Q9H8Y5	—	0.982	Q9H8Y5 →
Q0QWG9	—	0.982	Q0QWG9 →
Q9BXL6	—	0.982	Q9BXL6 →
Q96K21	—	0.982	Q96K21 →
A9JTG5	—	0.982	A9JTG5 →
Q8R5F8	—	0.981	Q8R5F8 →
GRB7	Growth factor receptor-bound protein 7	0.981	landscape →
MUS81	Structure-specific endonuclease subunit MUS81	0.981	landscape →
Q6F5E8	—	0.981	Q6F5E8 →
Q8TE68	—	0.981	Q8TE68 →
Q8C2K1	—	0.981	Q8C2K1 →
Q9ESJ4	—	0.980	Q9ESJ4 →
D3ZND0	—	0.980	D3ZND0 →
Q6V7V2	—	0.980	Q6V7V2 →
Q80UW5	—	0.980	Q80UW5 →
Q8C0R7	—	0.980	Q8C0R7 →
Q9NRS6	—	0.980	Q9NRS6 →