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Sugi Predict / Targets / PLEKHA1

PLEKHA1

Pleckstrin homology domain-containing family A member 1 · Q9HB21 · PLEKHA1 on Sugi Atlas →

32 patent compounds predicted against PLEKHA1, 16 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Hydrochloric Acid Hydrochloric Acid (SCHEMBL20983704) 0.58 2/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL26921279) 0.51 2/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL26923029) 0.51 2/20
SCHEMBL2519423 SCHEMBL2519423 0.40 2/20
SCHEMBL2519428 SCHEMBL2519428 0.40 2/20
SCHEMBL2519429 SCHEMBL2519429 0.40 2/20
SCHEMBL1187935 SCHEMBL1187935 0.38 2/20
SCHEMBL1187938 SCHEMBL1187938 0.38 2/20
SCHEMBL13759537 SCHEMBL13759537 0.34 2/20
SCHEMBL122211 SCHEMBL122211 0.55 1/20
SCHEMBL150406 SCHEMBL150406 0.55 1/20
SCHEMBL14592141 SCHEMBL14592141 0.55 1/20
SCHEMBL5350096 SCHEMBL5350096 0.46 1/20
SCHEMBL14592144 SCHEMBL14592144 0.46 1/20
SCHEMBL22063459 SCHEMBL22063459 0.44 1/20
SCHEMBL22672833 SCHEMBL22672833 0.44 1/20

Clinical trials — most relevant to PLEKHA1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma PHASE2RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Study of a c-Met Inhibitor PLB1001 in Patients With PTPRZ1-MET Fusion Gene Positive Recurrent High-grade Gliomas PHASE1COMPLETED
Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease. PHASE1COMPLETED
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA nanRECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Genetic Characterization of Parkinson's Disease nanCOMPLETED
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease. nanUNKNOWN
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations nanCOMPLETED
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks nanRECRUITING
The Chinese Pulmonary Lymphoepithelioma-like Carcinoma Collaboration Study nanRECRUITING
A Family Study of Copy Number Variations in Patients With Autism Spectrum Disorder nanCOMPLETED
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization nanCOMPLETED
Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome nanACTIVE_NOT_RECRUITING
PCD New Gene Discovery nanCOMPLETED
Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank nanCOMPLETED
Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Genetic Study of Familial Epilepsy nanCOMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Rostock International Parkinson's Disease Study (ROPAD) nanCOMPLETED
Genetic Variation in TRAF3IP2 (rs13190932) nanRECRUITING
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations nanWITHDRAWN
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome nanRECRUITING
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD) nanCOMPLETED
Gene Analysis of Parkinson's Disease nanCOMPLETED
Germline Mutations in Pancreatic Adenocarcinoma nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF) nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a PLEKHA1 binder may also engage these)

ProteinNameSimilarity
Q8BUL6 — 0.998 Q8BUL6 →
Q3ZBA3 — 0.981 Q3ZBA3 →
Q9HB19 — 0.978 Q9HB19 →
Q9ERS5 — 0.975 Q9ERS5 →
Q9Z1T4 — 0.969 Q9Z1T4 →
Q8WXI2 — 0.968 Q8WXI2 →
PRKD1 Serine/threonine-protein kinase D1 0.964 landscape →
Q80YA9 — 0.964 Q80YA9 →
Q7YQL6 — 0.963 Q7YQL6 →
Q99J31 — 0.963 Q99J31 →
Q7YQL5 — 0.962 Q7YQL5 →
O60890 — 0.961 O60890 →
Q3KR37 — 0.961 Q3KR37 →
O75563 — 0.961 O75563 →
Q6ZQ82 — 0.960 Q6ZQ82 →
P0CAX5 — 0.960 P0CAX5 →
E1C1R4 — 0.960 E1C1R4 →
USP47 Ubiquitin carboxyl-terminal hydrolase 47 0.959 landscape →
Q8K1Y2 — 0.959 Q8K1Y2 →
Q32LP7 — 0.959 Q32LP7 →
Q9UNA1 — 0.959 Q9UNA1 →
Q5U252 — 0.958 Q5U252 →
Q62101 — 0.958 Q62101 →
Q7Z6G8 — 0.957 Q7Z6G8 →
Q8BY87 — 0.957 Q8BY87 →
Q6Y5D8 — 0.957 Q6Y5D8 →
Q08DP6 — 0.957 Q08DP6 →
Q9WTQ1 — 0.957 Q9WTQ1 →
Q5RDS2 — 0.957 Q5RDS2 →
Q5RA30 — 0.956 Q5RA30 →