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THRAP3

Thyroid hormone receptor-associated protein 3 · Q9Y2W1 · THRAP3 on Sugi Atlas →

528 patent compounds predicted against THRAP3, 441 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Amg-900 Amg-900 (SCHEMBL503564) 1.00 1/20
Amg-900 Amg-900 (SCHEMBL29351414) 1.00 1/20
Amg-900 Amg-900 (SCHEMBL29479191) 1.00 1/20
SCHEMBL581178 SCHEMBL581178 0.84 1/20
SCHEMBL580354 SCHEMBL580354 0.84 1/20
SCHEMBL581542 SCHEMBL581542 0.82 1/20
SCHEMBL581159 SCHEMBL581159 0.81 1/20
SCHEMBL16290183 SCHEMBL16290183 0.81 1/20
SCHEMBL580342 SCHEMBL580342 0.80 1/20
SCHEMBL580529 SCHEMBL580529 0.78 1/20
SCHEMBL580667 SCHEMBL580667 0.78 1/20
SCHEMBL580290 SCHEMBL580290 0.78 1/20
SCHEMBL581658 SCHEMBL581658 0.78 1/20
SCHEMBL580671 SCHEMBL580671 0.77 1/20
SCHEMBL580463 SCHEMBL580463 0.77 1/20
SCHEMBL580539 SCHEMBL580539 0.76 1/20
SCHEMBL581766 SCHEMBL581766 0.75 1/20
SCHEMBL580692 SCHEMBL580692 0.74 1/20
SCHEMBL580740 SCHEMBL580740 0.73 1/20
SCHEMBL581772 SCHEMBL581772 0.73 1/20

Clinical trials — most relevant to THRAP3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused by Thyroidectomy in Thyroid Cancer Patients. PHASE4UNKNOWN
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome) PHASE2/PHASE3UNKNOWN
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study) PHASE3RECRUITING
Radiofrequency Ablation in TIR3A Nodules With Negative Genetic Evaluation nanUNKNOWN
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism nanUNKNOWN
Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome nanUNKNOWN
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3 nanCOMPLETED
Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment nanCOMPLETED
Genetic Analysis of Thyrotoxic Periodic Paralysis nanCOMPLETED
Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects nanRECRUITING
Register for Patients With Thyroid Hormone Resistance. nanRECRUITING
Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis nanCOMPLETED
Thyroid Hormones in CKD nanNOT_YET_RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Family Blood Pressure Program - GenNet Network nanCOMPLETED
A Gene Hunting Study for Familial Papillary Thyroid Cancer nanACTIVE_NOT_RECRUITING
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization nanCOMPLETED
TSH Receptor Mutations Among a Consanguineous Community nanCOMPLETED
Effect of Exercise on Irisin Levels of Hypothyroid Rats nanCOMPLETED
Family Blood Pressure Program - HyperGEN nanCOMPLETED
Epidemiology of Pituitary Tumours: Prevalence of Associated Neoplasia nanUNKNOWN
Comparison of Thyroid Volumes in Patients With and Without Endometrioma nanCOMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI nanRECRUITING
Family Blood Pressure Program - SAPPHIRe Network nanCOMPLETED
Family Blood Pressure Program - GENOA nanCOMPLETED
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans nanUNKNOWN
Efficacy and Prognosis of Microwave Ablation Treatment for Papillary Thyroid Microcarcinoma Assessed by Contrast-Enhanced Ultrasound Combined With Genetic and Molecular Diagnostics: A Prospective Observational Study nanRECRUITING
Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism nanUNKNOWN
Molecular Analysis for Precision Surgery in Thyroid Cancer Trial nanCOMPLETED
Clinical and Genetic Studies in Familial Non-medullary Thyroid Cancer nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a THRAP3 binder may also engage these)

ProteinNameSimilarity
Q569Z6 — 1.000 Q569Z6 →
Q5BJ39 — 1.000 Q5BJ39 →
Q5M7V8 — 1.000 Q5M7V8 →
BCLAF1 Bcl-2-associated transcription factor 1 1.000 landscape →
Q8K019 — 1.000 Q8K019 →
Q99PP2 — 0.992 Q99PP2 →
Q5VUA4 — 0.991 Q5VUA4 →
Q14151 — 0.987 Q14151 →
AFF4 AF4/FMR2 family member 4 0.987 landscape →
Q80YR5 — 0.986 Q80YR5 →
Q61464 — 0.985 Q61464 →
Q5CZI8 — 0.985 Q5CZI8 →
Q9Y2H5 — 0.984 Q9Y2H5 →
Q9ESC8 — 0.984 Q9ESC8 →
G3X9Z4 — 0.984 G3X9Z4 →
A0JMU8 — 0.984 A0JMU8 →
AFF1 AF4/FMR2 family member 1 0.983 landscape →
Q63014 — 0.983 Q63014 →
P59808 — 0.983 P59808 →
Q6UB99 — 0.983 Q6UB99 →
O88573 — 0.983 O88573 →
Q8BZ47 — 0.983 Q8BZ47 →
O15234 — 0.982 O15234 →
D3YXK2 — 0.982 D3YXK2 →
Q27IV2 — 0.982 Q27IV2 →
O35691 — 0.982 O35691 →
O43823 — 0.982 O43823 →
P0DW16 — 0.982 P0DW16 →
BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 0.982 landscape →
Q7TPM1 — 0.982 Q7TPM1 →