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Sugi Predict / Targets / PPIL1

PPIL1

Peptidyl-prolyl cis-trans isomerase-like 1 · Q9Y3C6 · PPIL1 on Sugi Atlas →

12 patent compounds predicted against PPIL1, 10 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL16550478 SCHEMBL16550478 1.00 1/20
SCHEMBL16550490 SCHEMBL16550490 0.56 1/20
SCHEMBL12733130 SCHEMBL12733130 0.49 1/20
SCHEMBL3360547 SCHEMBL3360547 0.46 1/20
SCHEMBL16016168 SCHEMBL16016168 0.45 1/20
Bromide Bromide (SCHEMBL3516464) 0.45 1/20
SCHEMBL30799263 SCHEMBL30799263 0.43 1/20
SCHEMBL27914923 SCHEMBL27914923 0.41 1/20
SCHEMBL30799232 SCHEMBL30799232 0.41 1/20
SCHEMBL30335806 SCHEMBL30335806 0.40 1/20

Clinical trials — most relevant to PPIL1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia PHASE3COMPLETED
A Multicenter Study of NAP (AL-108) in Schizophrenia PHASE2COMPLETED
Biomarker Strategies for Medication-Enhanced Cognitive Training in Schizophrenia PHASE1/PHASE2COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn PHASE1COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors PHASE1COMPLETED
Identification of Acute Intermittent Porphyria Modifying Genes nanRECRUITING
A Study on Psychopathological Progress of Early Schizophrenia-Like Disorder (SOPRES) nanUNKNOWN
Clubfoot DNA Repository nanCOMPLETED
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease nanCOMPLETED
Cerebellar Mutism Syndrome Study nanRECRUITING
Clinical Diagnosis of Acute Porphyria nanCOMPLETED
Genotype-supported Versus Conventional Proton Pump Inhibitor Dosing nanCOMPLETED
Expression of Markers Related to Mitochondrial Functionality in Carcinoma of the Urinary Bladder: Comparative Retrospective Analysis Between Recurrent Tumors (Non-responders) and Non-recurrent Tumors (Responders) After Intravesical Treatment With Chemotherapy or Immunotherapy nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC)) nanCOMPLETED
Biomarkers in the Diagnosis and Prognosis of NAFLD nanRECRUITING
Abnormal Expression Proteins, Mitochondrial DNA and miRNA of Irritable Bowel Syndrome nanUNKNOWN
Parkinson's Diseases Susceptibility Genes and Pesticides nanCOMPLETED
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia nanRECRUITING
Studies in Porphyria I: Characterization of Enzyme Defects nanUNKNOWN
Longitudinal Study of the Porphyrias nanRECRUITING
Biomarkers in Idiopathic Juvenile Arthritis nanUNKNOWN
LIPCAR, Cuproptosis, and Α-SMA in the Pathogenesis of AMI and Remodeling nanNOT_YET_RECRUITING
Autophagy Bladder Cancer nanUNKNOWN
Effect of Exercise Training on Protein Expression in Skeletal Muscle Tissue After Exercise in Peripheral Arterial Disease nanCOMPLETED
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis nanCOMPLETED
Adiposity and Immunometabolism in Sepsis nanUNKNOWN
Portable Measurement of Protoporphyrin IX in the Skin nanCOMPLETED
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PPIL1 binder may also engage these)

ProteinNameSimilarity
Q9D0W5 — 1.000 Q9D0W5 →
Q5E992 — 1.000 Q5E992 →
P0CP86 — 0.993 P0CP86 →
P0C1I4 — 0.992 P0C1I4 →
P0CP84 — 0.991 P0CP84 →
Q9SIH1 — 0.991 Q9SIH1 →
P0CP85 — 0.990 P0CP85 →
Q5ASQ0 — 0.989 Q5ASQ0 →
Q8X191 — 0.989 Q8X191 →
Q4PCH8 — 0.989 Q4PCH8 →
P9WHW2 — 0.988 P9WHW2 →
P65763 — 0.988 P65763 →
P0C1I5 — 0.987 P0C1I5 →
Q9H2H8 — 0.987 Q9H2H8 →
P0CP87 — 0.986 P0CP87 →
P87051 — 0.986 P87051 →
P9WHW3 — 0.986 P9WHW3 →
Q7SF72 — 0.985 Q7SF72 →
Q4WCR3 — 0.985 Q4WCR3 →
Q812D3 — 0.985 Q812D3 →
Q8SRE1 — 0.985 Q8SRE1 →
Q9CDE9 — 0.985 Q9CDE9 →
P0CP83 — 0.984 P0CP83 →
P0CP82 — 0.984 P0CP82 →
Q4WCM6 — 0.983 Q4WCM6 →
Q9LPC7 — 0.983 Q9LPC7 →
P52018 — 0.983 P52018 →
Q2TZ33 — 0.983 Q2TZ33 →
P0C1I8 — 0.983 P0C1I8 →
B3A0R0 — 0.982 B3A0R0 →