PRPF8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to PRPF8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Personalized Antisense Oligonucleotide Therapy for a Single Participant With PRPH2 Mutation Associated With Retinal Dystrophy	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
SAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects	PHASE1	COMPLETED
MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby)	PHASE1	COMPLETED
Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa	nan	COMPLETED
Natural History of PRPF31 Mutation-Associated Retinal Dystrophy	nan	ACTIVE_NOT_RECRUITING
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia	nan	RECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
Genetic Investigation of Cancer Predisposition	nan	NOT_YET_RECRUITING
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
SRSF2 Gene Mutation in Patients With t-MDS/AML	nan	COMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Identification and Characterization of Novel Non-Coding Variants That Contribute to Genetic Disorders	nan	COMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF)	nan	COMPLETED
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
Venous Thromboembolism in Myotonic Dystrophy Type 1	nan	COMPLETED
Identification of New FTLD Genes	nan	UNKNOWN
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Mutations and Phenotypes of Unclassifiable Inherited Bone Marrow Failure Syndromes	nan	RECRUITING
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Patient's Derived Organoids for Drug Screening in Glioblastoma	nan	NOT_YET_RECRUITING
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing	nan	NOT_YET_RECRUITING
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)	nan	RECRUITING
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks	nan	RECRUITING
Study of Constitutional Platelet Disease	nan	UNKNOWN
Mechanisms of Cell Death in Spinal Muscular Atrophy	nan	COMPLETED
Expression Pattern of HNRNPH1 and HNRNPK Genes in MPNs	nan	UNKNOWN
Natural History Study for Patients With Nemaline Myopathy in the UK	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a PRPF8 binder may also engage these)

Protein	Name	Similarity
Q99PV0	—	1.000	Q99PV0 →
P34369	—	1.000	P34369 →
O14187	—	1.000	O14187 →
Q9SSD2	—	1.000	Q9SSD2 →
Q9T0I6	—	0.999	Q9T0I6 →
Q8T295	—	0.998	Q8T295 →
Q9E005	—	0.990	Q9E005 →
P54634	—	0.990	P54634 →
P36791	—	0.989	P36791 →
Q5MNV8	—	0.989	Q5MNV8 →
P28897	—	0.988	P28897 →
P89034	—	0.988	P89034 →
Q96SK2	—	0.988	Q96SK2 →
Q9CQA8	—	0.988	Q9CQA8 →
P23456	—	0.988	P23456 →
Q80930	—	0.987	Q80930 →
PHKB	Phosphorylase kinase beta subunit	0.987	landscape →
O61608	—	0.987	O61608 →
Q80WL2	—	0.987	Q80WL2 →
Q9YQR5	—	0.987	Q9YQR5 →
Q3ZN07	—	0.987	Q3ZN07 →
Q806Y6	—	0.986	Q806Y6 →
P33334	—	0.986	P33334 →
Q5GT42	—	0.986	Q5GT42 →
Q84294	—	0.986	Q84294 →
Q9VR99	—	0.986	Q9VR99 →
Q9BXB7	—	0.986	Q9BXB7 →
M9RZ95	—	0.986	M9RZ95 →
P53938	—	0.986	P53938 →
E9PVB5	—	0.986	E9PVB5 →