PRSS8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL12247924	1.00	2/20
SCHEMBL12247928	1.00	2/20
SCHEMBL12247739	0.83	2/20
SCHEMBL12247740	0.83	2/20
SCHEMBL12247726	0.82	2/20
SCHEMBL12247911	0.82	2/20
SCHEMBL8230297	0.79	2/20
SCHEMBL12247732	0.79	2/20
SCHEMBL8230740	0.78	2/20
SCHEMBL8232358	0.78	2/20
SCHEMBL8233476	0.77	2/20
SCHEMBL8226682	0.73	2/20
SCHEMBL12247896	0.71	2/20
SCHEMBL8234179	0.71	2/20
SCHEMBL12247769	0.70	2/20
SCHEMBL8225384	0.70	2/20
SCHEMBL8230745	0.70	2/20
SCHEMBL12247741	0.70	2/20
SCHEMBL8232353	0.69	2/20
SCHEMBL8225253	0.69	2/20

Clinical trials — most relevant to PRSS8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus	PHASE2	UNKNOWN
Genetic Basis of Abdominal Aortic Aneurysm	nan	COMPLETED
Study of Tissue, Blood, and Urine Samples From Patients With Advanced Prostate Cancer	nan	UNKNOWN
PRospective Prostate biOmarker Study	nan	COMPLETED
Genetics of Hypertension and Its Intermediate Phenotypes	nan	COMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
Genetic and Non-Genetic Breast Cancer Risk Prediction Evaluation in Indonesian Samples	nan	COMPLETED
A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity	nan	NOT_YET_RECRUITING
Performance of Inherited Risk Assessment for Predicting Prostate Cancer From Prostate Biopsy	nan	RECRUITING
SLPI for Prostate Cancer	nan	UNKNOWN
Personalized Breast Cancer Screening	nan	ACTIVE_NOT_RECRUITING
PAR Family Polymorphisms and Placental Invasion Disorders	nan	UNKNOWN
Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)	nan	RECRUITING
A Tailored Polygenic Risk Score for Predicting Progression in Prostate Cancer Under Active Surveillance	nan	COMPLETED
Prostate Cancer Risk Identification in a Multi-Ethnic Cohort: a Prospective US-based Multi-center Validation Study of Proclarix	nan	RECRUITING
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations	nan	COMPLETED
Familial Prostate Cancer	nan	COMPLETED
Identifying PARDS Endotypes	nan	COMPLETED
Genetics of Prostate Cancer in Young Patients	nan	COMPLETED
MMP Polymorphisms and Acute Coronary Syndromes	nan	COMPLETED
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment	nan	RECRUITING
Proteases in Patients With Prostate Cancer That Has Spread to the Bone	nan	COMPLETED
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage	nan	ENROLLING_BY_INVITATION
Family Blood Pressure Program - GENOA	nan	COMPLETED
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
The Genetics of Environmental Asthma	nan	COMPLETED
The BARCODE 1 Pilot Study	nan	ACTIVE_NOT_RECRUITING
The Investigation of New Biological Markers for Prostate Cancer Diagnosis and Management in Chinese Population	nan	RECRUITING
Genetic Studies of Prostate Cancer Aggressiveness and Prognosis	nan	COMPLETED
Peri-implantitis and MMP-8	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PRSS8 binder may also engage these)

Protein	Name	Similarity
Q9ESD1	—	1.000	Q9ESD1 →
Q9ES87	—	1.000	Q9ES87 →
P83748	—	1.000	P83748 →
Q8BJR6	—	0.992	Q8BJR6 →
Q9GZN4	—	0.992	Q9GZN4 →
Q7Z5A4	—	0.990	Q7Z5A4 →
Q6BEA2	—	0.990	Q6BEA2 →
A1L453	—	0.990	A1L453 →
Q5K2P8	—	0.990	Q5K2P8 →
Q9QYZ9	—	0.990	Q9QYZ9 →
Q402U7	—	0.989	Q402U7 →
Q14B25	—	0.988	Q14B25 →
Q7RTY5	—	0.988	Q7RTY5 →
Q8K4I7	—	0.988	Q8K4I7 →
Q9Y6M0	—	0.988	Q9Y6M0 →
Q9QUL7	—	0.986	Q9QUL7 →
Q571E5	—	0.986	Q571E5 →
A6NIE9	—	0.986	A6NIE9 →
A2VE36	—	0.985	A2VE36 →
Q6UWB4	—	0.984	Q6UWB4 →
Q920S2	—	0.983	Q920S2 →
Q3UKY7	—	0.983	Q3UKY7 →
Q9ER04	—	0.983	Q9ER04 →
Q9H3S3	—	0.983	Q9H3S3 →
Q9UI38	—	0.983	Q9UI38 →
Q5K2P9	—	0.983	Q5K2P9 →
Q9ER10	—	0.983	Q9ER10 →
Q5K4E3	—	0.982	Q5K4E3 →
Q9BQR3	—	0.982	Q9BQR3 →
Q6IE62	—	0.981	Q6IE62 →