PRSS8 — 37 ClinVar variants
All ClinVar germline PRSS8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Benign · 5 Likely benign · 31 Uncertain significance
Full PRSS8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRSS8 p.Ala160Thr Uncertain significance Single submitter
- PRSS8 p.Ala317Gly Uncertain significance Single submitter
- PRSS8 p.Ala95Val Uncertain significance Single submitter
- PRSS8 p.Arg44Cys Uncertain significance Single submitter
- PRSS8 p.Asp237Ala Uncertain significance Single submitter
- PRSS8 p.Asp302Asn Uncertain significance Single submitter
- PRSS8 p.Cys201Tyr Uncertain significance Single submitter
- PRSS8 p.Cys37Arg Uncertain significance Single submitter
- PRSS8 p.Gln218His Uncertain significance Single submitter
- PRSS8 p.Gln297Arg Uncertain significance Single submitter
- PRSS8 p.Glu90Lys Uncertain significance Single submitter
- PRSS8 p.Gly13Ala Uncertain significance Single submitter
- PRSS8 p.Gly29Glu Uncertain significance Single submitter
- PRSS8 p.Gly5Glu Uncertain significance Single submitter
- PRSS8 p.His123Asn Uncertain significance Single submitter
- PRSS8 p.His309Tyr Uncertain significance Single submitter
- PRSS8 p.His68Arg Uncertain significance Single submitter
- PRSS8 p.Ile135Val Uncertain significance Single submitter
- PRSS8 p.Leu288Phe Uncertain significance Single submitter
- PRSS8 p.Leu305Arg Uncertain significance Single submitter
- PRSS8 p.Lys113Thr Uncertain significance Single submitter
- PRSS8 p.Pro187Thr Uncertain significance Single submitter
- PRSS8 p.Pro41Thr Uncertain significance Single submitter
- PRSS8 p.Ser283Asn Uncertain significance Single submitter
- PRSS8 p.Val176Met Uncertain significance Single submitter
- PRSS8 p.Val292Met Uncertain significance Single submitter
- PRSS8 p.Val6Phe Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All PRSS8 variants
Benign 1
- p.Gly8Glu Multiple submitters
Likely benign 5
- p.Arg25Gln Single submitter
- p.Arg291His Single submitter
- p.Asp208Asn Single submitter
- p.Ser89= Single submitter
- p.Val67Ile Single submitter
Uncertain significance 31
- p.Ala160Thr Single submitter ⚠
- p.Ala233Thr Single submitter
- p.Ala278Pro Single submitter ⚠
- p.Ala317Gly Single submitter ⚠
- p.Ala95Val Single submitter ⚠
- p.Arg44Cys Single submitter ⚠
- p.Asp237Ala Single submitter ⚠
- p.Asp302Asn Single submitter ⚠
- p.Cys201Tyr Single submitter ⚠
- p.Cys37Arg Single submitter ⚠
- p.Gln218His Single submitter ⚠
- p.Gln297Arg Single submitter ⚠
- p.Glu90Lys Single submitter ⚠
- p.Gly13Ala Single submitter ⚠
- p.Gly29Glu Single submitter ⚠
- p.Gly5Glu Single submitter ⚠
- p.His123Asn Single submitter ⚠
- p.His309Tyr Single submitter ⚠
- p.His68Arg Single submitter ⚠
- p.Ile135Val Single submitter ⚠
- p.Leu105Arg Single submitter ⚠
- p.Leu288Phe Single submitter ⚠
- p.Leu305Arg Single submitter ⚠
- p.Lys113Thr Single submitter ⚠
- p.Pro187Thr Single submitter ⚠
- p.Pro41Thr Single submitter ⚠
- p.Ser283Asn Single submitter ⚠
- p.Thr200Arg Single submitter
- p.Val176Met Single submitter ⚠
- p.Val292Met Single submitter ⚠
- p.Val6Phe Single submitter ⚠