PSMA8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL605949	0.54	15/20
SCHEMBL1478606	0.58	12/20
SCHEMBL607010	0.56	12/20
SCHEMBL609327	0.55	12/20
SCHEMBL1478372	0.55	12/20
SCHEMBL607553	0.54	12/20
SCHEMBL606932	0.53	12/20
SCHEMBL608381	0.53	12/20
SCHEMBL1477893	0.53	12/20
SCHEMBL609081	0.52	12/20
SCHEMBL606926	0.52	12/20
SCHEMBL606344	0.51	12/20
SCHEMBL606616	0.51	12/20
SCHEMBL1327404	0.50	12/20
SCHEMBL607035	0.61	11/20
SCHEMBL609733	0.60	11/20
SCHEMBL609324	0.60	11/20
SCHEMBL605158	0.59	11/20
SCHEMBL606315	0.59	11/20
SCHEMBL1477637	0.57	11/20

Clinical trials — most relevant to PSMA8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients	PHASE4	NOT_YET_RECRUITING
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease	PHASE4	UNKNOWN
The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy	PHASE2	NOT_YET_RECRUITING
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
MLN9708 and Dexamethasone for High-Risk Smoldering Multiple Myeloma	PHASE2	WITHDRAWN
PS-341 Followed by Removal of Prostate for Those With Prostate Cancer	PHASE2	COMPLETED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer	PHASE2	COMPLETED
Colchicine for Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma	PHASE2	WITHDRAWN
Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer	PHASE1	COMPLETED
Extended Infusion Carfilzomib on a Weekly Schedule in Patients With Advanced Solid Tumors	PHASE1	COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Study of Patients With Stage IV Malignant Melanoma Using PS-341 (Bortezomib, Velcade) and Interferon-alpha-2b in Malignant Melanoma	PHASE1	COMPLETED
GO-203-2C + Bortezomib For Relapsed Or Refractory MM	PHASE1	WITHDRAWN
Study of Irinotecan and Bortezomib in Children With Recurrent/Refractory Neuroblastoma	PHASE1	COMPLETED
Bortezomib and Carboplatin in Treating Patients With Recurrent or Progressive Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer	PHASE1	COMPLETED
Evaluation of Proteasome as a Marker of Hepatocellular Carcinoma in Cirrhotic Patients Following Curative Treatment	nan	UNKNOWN
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Cardiovascular Complications of Carfilzomib Treatment	nan	UNKNOWN
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis	nan	UNKNOWN
Impact of O6-methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients (MGMT)	nan	UNKNOWN
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
The PREServation of MUScle Function in Critically Ill Patients (PRESMUS)	nan	UNKNOWN
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
The Efficiency of Postoperative Interferon-alpha Treatment in p48 Positive Patients With Hepatocellular Carcinoma	nan	WITHDRAWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PSMA8 binder may also engage these)

Protein	Name	Similarity
Q9CWH6	—	1.000	Q9CWH6 →
O13268	—	1.000	O13268 →
Q9Z2U0	—	1.000	Q9Z2U0 →
Q5RDH8	—	1.000	Q5RDH8 →
Q9PVQ1	—	1.000	Q9PVQ1 →
O16811	—	1.000	O16811 →
PSMA7	Proteasome subunit alpha type-7	1.000	landscape →
Q3ZBG0	—	1.000	Q3ZBG0 →
P22769	—	1.000	P22769 →
P48004	—	1.000	P48004 →
Q9PTW9	—	1.000	Q9PTW9 →
Q4R7D9	—	1.000	Q4R7D9 →
O24616	—	1.000	O24616 →
Q0J006	—	1.000	Q0J006 →
A2YXU2	—	1.000	A2YXU2 →
Q9PVY6	—	1.000	Q9PVY6 →
P40303	—	1.000	P40303 →
Q24178	—	1.000	Q24178 →
P30186	—	0.999	P30186 →
A2Z3I9	—	0.999	A2Z3I9 →
P21243	—	0.999	P21243 →
Q54XM7	—	0.999	Q54XM7 →
Q9XZJ4	—	0.998	Q9XZJ4 →
Q6YT00	—	0.998	Q6YT00 →
P18422	—	0.998	P18422 →
Q27488	—	0.997	Q27488 →
Q9V5C6	—	0.997	Q9V5C6 →
O94517	—	0.997	O94517 →
Q3T0X5	—	0.997	Q3T0X5 →
O24030	—	0.996	O24030 →