PSMA8 — 38 ClinVar variants
All ClinVar germline PSMA8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Likely benign · 37 Uncertain significance
Full PSMA8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSMA8 c.230-2A>G Uncertain significance Single submitter
- PSMA8 p.Ala193Thr Uncertain significance Single submitter
- PSMA8 p.Ala211Gly Uncertain significance Single submitter
- PSMA8 p.Ala27Thr Uncertain significance Single submitter
- PSMA8 p.Ala34Val Uncertain significance Single submitter
- PSMA8 p.Arg111Cys Uncertain significance Single submitter
- PSMA8 p.Arg7Trp Uncertain significance Single submitter
- PSMA8 p.Arg90Cys Uncertain significance Single submitter
- PSMA8 p.Arg90Pro Uncertain significance Single submitter
- PSMA8 p.Asn216Ser Uncertain significance Single submitter
- PSMA8 p.Asn41Ser Uncertain significance Single submitter
- PSMA8 p.Asp57Gly Uncertain significance Single submitter
- PSMA8 p.Asp68Gly Uncertain significance Single submitter
- PSMA8 p.Glu92Gly Uncertain significance Single submitter
- PSMA8 p.Gly164Ala Uncertain significance Single submitter
- PSMA8 p.Ile109Thr Uncertain significance Single submitter
- PSMA8 p.Ile194Arg Uncertain significance Single submitter
- PSMA8 p.Ile208Phe Uncertain significance Single submitter
- PSMA8 p.Ile212Val Uncertain significance Single submitter
- PSMA8 p.Ile42Met Uncertain significance Single submitter
- PSMA8 p.Lys119Gln Uncertain significance Single submitter
- PSMA8 p.Lys225Arg Uncertain significance Single submitter
- PSMA8 p.Lys97Arg Uncertain significance Single submitter
- PSMA8 p.Ser32Phe Uncertain significance Single submitter
- PSMA8 p.Thr179Ile Uncertain significance Single submitter
- PSMA8 p.Val106Ile Uncertain significance Single submitter
- PSMA8 p.Val170Ile Uncertain significance Single submitter
- PSMA8 p.Val43Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PSMA8 p.Arg165Gln Uncertain significance Single submitter
- PSMA8 p.His156Asp Uncertain significance Single submitter
- PSMA8 p.Ile213Lys Uncertain significance Single submitter
- PSMA8 p.Lys191Glu Uncertain significance Single submitter
- PSMA8 p.Lys30Asn Uncertain significance Single submitter
- PSMA8 p.Phe75Val Uncertain significance Single submitter
- PSMA8 p.Val85Ala Uncertain significance Single submitter
All PSMA8 variants
Likely benign 1
- c.230-4A>G Single submitter
Uncertain significance 37
- c.230-2A>G Single submitter ⚠
- p.Ala193Thr Single submitter ⚠
- p.Ala211Gly Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala34Val Single submitter ⚠
- p.Arg111Cys Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg7Trp Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Arg90Pro Single submitter ⚠
- p.Asn216Ser Single submitter ⚠
- p.Asn41Ser Single submitter ⚠
- p.Asp57Gly Single submitter ⚠
- p.Asp68Gly Single submitter ⚠
- p.Glu92Gly Single submitter ⚠
- p.Gly164Ala Single submitter ⚠
- p.His156Asp Single submitter ⚠
- p.Ile109Thr Single submitter ⚠
- p.Ile190Thr Single submitter
- p.Ile194Arg Single submitter ⚠
- p.Ile208Phe Single submitter ⚠
- p.Ile212Val Single submitter ⚠
- p.Ile213Lys Single submitter ⚠
- p.Ile42Met Single submitter ⚠
- p.Leu134Val Single submitter
- p.Lys119Gln Single submitter ⚠
- p.Lys191Glu Single submitter ⚠
- p.Lys225Arg Single submitter ⚠
- p.Lys30Asn Single submitter ⚠
- p.Lys97Arg Single submitter ⚠
- p.Phe75Val Single submitter ⚠
- p.Ser32Phe Single submitter ⚠
- p.Thr179Ile Single submitter ⚠
- p.Val106Ile Single submitter ⚠
- p.Val170Ile Single submitter ⚠
- p.Val43Leu Single submitter ⚠
- p.Val85Ala Single submitter ⚠