RAB10

Ras-related protein Rab-10 · P61026 · RAB10 on Sugi Atlas →

482 patent compounds predicted against RAB10, 421 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Alisertib (SCHEMBL855823)	1.00	1/20
Alisertib (SCHEMBL29354333)	1.00	1/20
Alisertib (SCHEMBL29437869)	1.00	1/20
Alisertib (SCHEMBL29720486)	1.00	1/20
Alisertib (SCHEMBL29750414)	1.00	1/20
Alisertib (SCHEMBL854553)	0.98	1/20
Alisertib (SCHEMBL15263514)	0.98	1/20
Alisertib (SCHEMBL14125416)	0.97	1/20
SCHEMBL2389378	0.94	1/20
SCHEMBL2389355	0.89	1/20
SCHEMBL2392579	0.89	1/20
SCHEMBL20214913	0.89	1/20
SCHEMBL12454978	0.89	1/20
SCHEMBL26005084	0.89	1/20
SCHEMBL2386771	0.87	1/20
Alisertib (SCHEMBL854552)	0.86	1/20
Alisertib (SCHEMBL29664627)	0.86	1/20
Alisertib (SCHEMBL30405892)	0.86	1/20
SCHEMBL12054412	0.86	1/20
SCHEMBL10072296	0.86	1/20

Clinical trials — most relevant to RAB10 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)	PHASE1/PHASE2	NOT_YET_RECRUITING
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients	PHASE1/PHASE2	COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC)	PHASE2	COMPLETED
Nilotinib in Huntington's Disease	PHASE1	UNKNOWN
Expression and Function of the Renin-Angiotensin System in the Esophagus	EARLY_PHASE1	COMPLETED
Identification of New Biomarkers of Insulin Resistance	nan	ACTIVE_NOT_RECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial	nan	RECRUITING
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients	nan	RECRUITING
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)	nan	COMPLETED
Fox BioNet Project: LRRK2-002	nan	COMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies	nan	RECRUITING
Clinical Genetics Branch Eligibility Screening Survey	nan	NOT_YET_RECRUITING
Prevalence and Characterization of Pain in RASopathies	nan	UNKNOWN
Parkinson's Families Project	nan	RECRUITING
RASopathy Biorepository	nan	RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Progression of Prodromal Markers of α-synucleinopathy Neurodegeneration in the FDRs of Patients With RBD	nan	COMPLETED
Role of Polymorphisms in the IL-1 Gene Cluster	nan	COMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population	nan	COMPLETED
Search for Genes Influencing Childhood Absence Epilepsy (CAE) Study	nan	COMPLETED
Genetics of Rolandic Epilepsy	nan	COMPLETED
Genetic Studies of Chronic Active Epstein-Barr Disease	nan	RECRUITING
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients	nan	COMPLETED
Gait in Rare Diseases	nan	COMPLETED
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RAB10 binder may also engage these)

Protein	Name	Similarity
P24409	—	1.000	P24409 →
Q5ZIT5	—	1.000	Q5ZIT5 →
P22127	—	1.000	P22127 →
Q5R5U1	—	1.000	Q5R5U1 →
Q9DD03	—	1.000	Q9DD03 →
P61027	—	1.000	P61027 →
Q92930	—	1.000	Q92930 →
P35281	—	1.000	P35281 →
P35280	—	1.000	P35280 →
P55258	—	1.000	P55258 →
F1PTE3	—	1.000	F1PTE3 →
Q7T3A4	—	1.000	Q7T3A4 →
Q9UL26	—	1.000	Q9UL26 →
P61007	—	1.000	P61007 →
P70550	—	1.000	P70550 →
P51153	—	1.000	P51153 →
P35286	—	0.999	P35286 →
Q13636	—	0.998	Q13636 →
Q9D1G1	—	0.998	Q9D1G1 →
RAB8A	Ras-related protein Rab-8A	0.998	landscape →
Q4R8X3	—	0.998	Q4R8X3 →
Q68EK7	—	0.998	Q68EK7 →
Q54NU2	—	0.998	Q54NU2 →
P36409	—	0.997	P36409 →
Q5REC9	—	0.997	Q5REC9 →
Q4R5P1	—	0.996	Q4R5P1 →
Q5F470	—	0.996	Q5F470 →
O42819	—	0.996	O42819 →
Q5KTJ6	—	0.996	Q5KTJ6 →
P22128	—	0.996	P22128 →