RAB10 — 10 ClinVar variants
All ClinVar germline RAB10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
1 Benign · 9 Uncertain significance
Full RAB10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RAB10 p.Arg172Gln Uncertain significance Single submitter
- RAB10 p.Asn156Asp Uncertain significance Single submitter
- RAB10 p.Gly135Ala Uncertain significance Single submitter
- RAB10 p.Ser101Thr Uncertain significance Single submitter
- RAB10 p.Thr165Met Uncertain significance Single submitter
- RAB10 p.Tyr89Cys Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RAB10 variants
Benign 1
- p.Thr174= Multiple submitters
Uncertain significance 9
- p.Arg172Gln Single submitter ⚠
- p.Asn156Asp Single submitter ⚠
- p.Gly135Ala Single submitter ⚠
- p.Lys129Glu Single submitter
- p.Ser101Thr Single submitter ⚠
- p.Ser197Ile Single submitter ⚠
- p.Thr165Met Single submitter ⚠
- p.Tyr89Cys Single submitter ⚠
- p.Val184Ala Single submitter ⚠