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Sugi Predict / Targets / RAB7A

RAB7A

Ras-related protein Rab-7a · P51149 · RAB7A on Sugi Atlas →

1,248 patent compounds predicted against RAB7A, 411 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15832852 SCHEMBL15832852 0.69 20/20
SCHEMBL15832893 SCHEMBL15832893 0.68 20/20
SCHEMBL15647854 SCHEMBL15647854 1.00 19/20
SCHEMBL16002213 SCHEMBL16002213 0.82 19/20
SCHEMBL16002185 SCHEMBL16002185 0.79 19/20
SCHEMBL16002090 SCHEMBL16002090 0.78 19/20
SCHEMBL15832869 SCHEMBL15832869 0.69 19/20
SCHEMBL15832878 SCHEMBL15832878 0.69 19/20
SCHEMBL15832875 SCHEMBL15832875 1.00 18/20
SCHEMBL15832884 SCHEMBL15832884 1.00 18/20
SCHEMBL15832891 SCHEMBL15832891 1.00 18/20
SCHEMBL15832860 SCHEMBL15832860 0.84 18/20
SCHEMBL16002160 SCHEMBL16002160 0.83 18/20
SCHEMBL15832866 SCHEMBL15832866 1.00 17/20
SCHEMBL15832889 SCHEMBL15832889 1.00 17/20
SCHEMBL15832861 SCHEMBL15832861 0.81 17/20
SCHEMBL15832857 SCHEMBL15832857 0.79 17/20
SCHEMBL15832883 SCHEMBL15832883 0.77 17/20
SCHEMBL15832862 SCHEMBL15832862 0.70 17/20
SCHEMBL15832845 SCHEMBL15832845 1.00 16/20

Clinical trials — most relevant to RAB7A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Study of Hydroxychloroquine in Combination With Gemcitabine/Abraxane in Pancreatic Cancer PHASE1/PHASE2COMPLETED
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin for Non-Small Cell Lung Cancer With KRAS or EGFR Activation PHASE2COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Study of Intratumoral REOLYSIN® in Combination With Gemcitabine and Cisplatin as Neoadjuvant Therapy in Muscle-invasive Transitional Cell Carcinoma of the Bladder PHASE1WITHDRAWN
Nilotinib in Huntington's Disease PHASE1UNKNOWN
Expression and Function of the Renin-Angiotensin System in the Esophagus EARLY_PHASE1COMPLETED
Identification of New Biomarkers of Insulin Resistance nanACTIVE_NOT_RECRUITING
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients nanRECRUITING
Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial nanRECRUITING
Autophagy Bladder Cancer nanUNKNOWN
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes nanCOMPLETED
Mutation of K-RAS, CDKN2A, SMAD4 and TP53 in Pancreatic Cancer: Role of Liquid Biopsy in Preoperative Diagnosis nanUNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Fox BioNet Project: LRRK2-002 nanCOMPLETED
Genotype-Phenotype Correlations of Late Infantile Neuronal Ceroid Lipofuscinosis nanCOMPLETED
Study of Chediak-Higashi Syndrome nanRECRUITING
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population nanCOMPLETED
Parkinson's Families Project nanRECRUITING
Natural History of Photoreceptor Degeneration in USH1B: Clinical Parameters and Validation of Functional Vision Tests in MYO7A nanRECRUITING
Natural History of Spinocerebellar Ataxia Type 7 (SCA7) nanRECRUITING
Joint and Hematologic Disorders of Noonan Syndrome: French Descriptive Cross-sectional Study nanCOMPLETED
Gait in Rare Diseases nanCOMPLETED
Value of MicroRNA30a in Philadelphia Positive Leukemic Patients nanUNKNOWN
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Genetics of Rolandic Epilepsy nanCOMPLETED
RASopathy Biorepository nanRECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Genetic Evaluation of NF1 and Scoliosis Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a RAB7A binder may also engage these)

ProteinNameSimilarity
P09527 — 1.000 P09527 →
Q3T0F5 — 1.000 Q3T0F5 →
Q5R9Y4 — 1.000 Q5R9Y4 →
O97572 — 1.000 O97572 →
P51150 — 1.000 P51150 →
H9BW96 — 1.000 H9BW96 →
P18067 — 1.000 P18067 →
P93267 — 0.998 P93267 →
Q39573 — 0.996 Q39573 →
Q9C820 — 0.996 Q9C820 →
Q9LW76 — 0.996 Q9LW76 →
P31022 — 0.995 P31022 →
Q9SJ11 — 0.995 Q9SJ11 →
Q41640 — 0.995 Q41640 →
Q9XER8 — 0.994 Q9XER8 →
C8VQY7 — 0.994 C8VQY7 →
Q9C2L8 — 0.994 Q9C2L8 →
O24461 — 0.993 O24461 →
Q43463 — 0.993 Q43463 →
Q9LS94 — 0.992 Q9LS94 →
O76742 — 0.992 O76742 →
Q40787 — 0.992 Q40787 →
RAB9A Ras-related protein Rab-9A 0.992 landscape →
Q948K8 — 0.991 Q948K8 →
O94655 — 0.991 O94655 →
P36864 — 0.991 P36864 →
Q9R0M6 — 0.991 Q9R0M6 →
P36411 — 0.991 P36411 →
G4MYS1 — 0.990 G4MYS1 →
Q9XI98 — 0.990 Q9XI98 →