RPS16 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16177128	1.00	9/20
SCHEMBL16177066	0.74	9/20
SCHEMBL16177239	0.74	9/20
SCHEMBL16177254	0.73	9/20
SCHEMBL16177161	0.49	8/20
SCHEMBL16177141	1.00	7/20
SCHEMBL16177219	0.71	7/20
SCHEMBL13625506	0.44	7/20
SCHEMBL16176812	0.73	4/20
SCHEMBL5500526	0.41	4/20
SCHEMBL5500532	0.41	4/20
SCHEMBL5503310	0.41	4/20
SCHEMBL11844361	0.35	4/20
SCHEMBL16176817	0.64	3/20
SCHEMBL16177306	0.64	3/20
SCHEMBL16177050	0.61	3/20
SCHEMBL16177120	0.61	3/20
SCHEMBL16177197	0.61	3/20
SCHEMBL16176805	0.58	3/20
SCHEMBL16177181	0.57	3/20

Clinical trials — most relevant to RPS16 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Everolimus for Children With Recurrent or Progressive Ependymoma	PHASE2	COMPLETED
Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer	PHASE1/PHASE2	COMPLETED
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients	PHASE1/PHASE2	COMPLETED
Antiviral Activity and Safety of 3 Different Doses of Mifepristone in Hepatitis C Infected Patients	PHASE2	COMPLETED
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety	PHASE2	COMPLETED
Open Label Study of Everolimus (RAD001) in Patients With Segmental Overgrowth Syndrome	PHASE2	WITHDRAWN
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia	PHASE1	RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer	PHASE1	WITHDRAWN
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
Mobilization of CD34+ Peripheral Blood Stem Cells in Patients With Diamond Blackfan Anemia Syndrome (DBAS)	nan	RECRUITING
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer	nan	UNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care	nan	COMPLETED
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
RibOSE - Glucose and Resistance Exercise Training	nan	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Shwachman Diamond Syndrome Registry and Study	nan	RECRUITING
Mitoquines in COPD	nan	UNKNOWN
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Cytomegalovirus (CMV) MicroRNA Expression in Vivo and Immune Evasion Correlates	nan	COMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Natural History and Genetic Studies of Usher Syndrome	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a RPS16 binder may also engage these)

Protein	Name	Similarity
P62250	—	1.000	P62250 →
G1SGX4	—	1.000	G1SGX4 →
Q3T0X6	—	1.000	Q3T0X6 →
Q29201	—	1.000	Q29201 →
P14131	—	1.000	P14131 →
Q90YQ7	—	0.973	Q90YQ7 →
Q98TR7	—	0.970	Q98TR7 →
Q0DK10	—	0.954	Q0DK10 →
P42794	—	0.953	P42794 →
P42795	—	0.951	P42795 →
A2YDY2	—	0.949	A2YDY2 →
P46287	—	0.947	P46287 →
RPS15A	Small ribosomal subunit protein uS8	0.939	landscape →
P62245	—	0.938	P62245 →
G1TU13	—	0.935	G1TU13 →
P62084	—	0.935	P62084 →
Q90YR7	—	0.935	Q90YR7 →
P02362	—	0.935	P02362 →
A5PK63	—	0.934	A5PK63 →
Q4R5I3	—	0.934	Q4R5I3 →
Q6NVL5	—	0.933	Q6NVL5 →
Q5RIC0	—	0.933	Q5RIC0 →
P62246	—	0.932	P62246 →
G1TG89	—	0.932	G1TG89 →
P50894	—	0.932	P50894 →
Q76I82	—	0.932	Q76I82 →
Q9H9T3	—	0.931	Q9H9T3 →
A6H769	—	0.931	A6H769 →
G1SVB0	—	0.931	G1SVB0 →
Q6Q420	—	0.930	Q6Q420 →