RPS18 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16189192	0.69	12/20
SCHEMBL21598983	0.65	11/20
SCHEMBL21599020	0.65	11/20
SCHEMBL16189119	0.68	10/20
SCHEMBL16177128	1.00	9/20
SCHEMBL16177345	1.00	9/20
SCHEMBL16177805	1.00	9/20
SCHEMBL16177066	0.74	9/20
SCHEMBL16177239	0.74	9/20
SCHEMBL16177254	0.73	9/20
SCHEMBL17536518	0.68	9/20
SCHEMBL17536553	0.66	9/20
SCHEMBL17536517	0.66	9/20
SCHEMBL17536519	0.64	9/20
SCHEMBL17536554	0.62	9/20
SCHEMBL21598955	0.54	9/20
SCHEMBL21599023	0.54	9/20
SCHEMBL21598989	0.52	9/20
SCHEMBL21599067	0.52	9/20
SCHEMBL16180190	0.81	8/20

Clinical trials — most relevant to RPS18 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Antiviral Activity and Safety of 3 Different Doses of Mifepristone in Hepatitis C Infected Patients	PHASE2	COMPLETED
Mobilization of Stem Cells With G-CSF for Collection From Patients With Diamond-Blackfan Anemia	PHASE2	COMPLETED
Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer	PHASE1/PHASE2	COMPLETED
Everolimus for Children With Recurrent or Progressive Ependymoma	PHASE2	COMPLETED
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients	PHASE1/PHASE2	COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia	PHASE1	RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer	PHASE1	WITHDRAWN
Mobilization of CD34+ Peripheral Blood Stem Cells in Patients With Diamond Blackfan Anemia Syndrome (DBAS)	nan	RECRUITING
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Cytomegalovirus (CMV) MicroRNA Expression in Vivo and Immune Evasion Correlates	nan	COMPLETED
Effect of Diaphragm Stimulation During Surgery	nan	COMPLETED
Mitoquines in COPD	nan	UNKNOWN
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma	nan	COMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis)	nan	COMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory	nan	COMPLETED
Natural History and Genetic Studies of Usher Syndrome	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RPS18 binder may also engage these)

Protein	Name	Similarity
Q3T0R1	—	1.000	Q3T0R1 →
P62270	—	1.000	P62270 →
Q90YQ5	—	1.000	Q90YQ5 →
Q5TJE9	—	1.000	Q5TJE9 →
Q8IT98	—	1.000	Q8IT98 →
G1TPG3	—	1.000	G1TPG3 →
A5JST6	—	1.000	A5JST6 →
P62272	—	1.000	P62272 →
Q962R1	—	1.000	Q962R1 →
P48151	—	1.000	P48151 →
Q869U7	—	1.000	Q869U7 →
Q8JGS9	—	1.000	Q8JGS9 →
Q8ISP0	—	1.000	Q8ISP0 →
P62271	—	1.000	P62271 →
P34788	—	0.999	P34788 →
O27999	—	0.997	O27999 →
O74021	—	0.997	O74021 →
P0CX56	—	0.996	P0CX56 →
A1RT04	—	0.996	A1RT04 →
P0CX55	—	0.996	P0CX55 →
P41094	—	0.996	P41094 →
P0CT66	—	0.995	P0CT66 →
P0CT67	—	0.994	P0CT67 →
Q97B96	—	0.993	Q97B96 →
A0A1D8PQQ5	—	0.993	A0A1D8PQQ5 →
A3MUT0	—	0.993	A3MUT0 →
O26141	—	0.993	O26141 →
Q8U0E2	—	0.992	Q8U0E2 →
B9K8B1	—	0.992	B9K8B1 →
Q2FT96	—	0.992	Q2FT96 →