Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | RRM1 | P23921 | 4/20 | 0.48 |
| ▸ | RRM2 | P31350 | 4/20 | 0.48 |
| ▸ | RRM2B | Q7LG56 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153460 | 0.73 | RRM1 (0.56) | MAPTRRM1RRM2RRM2BSMN1; SMN2 | |
| SCHEMBL6154732 | 0.72 | ALDH1A1 (0.68) | MAPTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL6154622 | 0.72 | SMN1; SMN2 (0.55) | MAPTRRM1RRM2RRM2BSMN1; SMN2 | |
| SCHEMBL4555003 | 0.69 | IDO1 (0.78) | MAPTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL6686025 | 0.67 | EPHX1 (0.67) | MAPTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11651251 | 0.66 | NPC1 (0.68) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL5450586 | 0.65 | ALDH1A1 (0.71) | MAPTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL12453319 | 0.65 | RAB9A (0.68) | RRM1RRM2RRM2BSMN1; SMN2KMT2A | |
| SCHEMBL28797194 | 0.65 | RAB9A (0.68) | RRM1RRM2RRM2BSMN1; SMN2KMT2A | |
| SCHEMBL10660750 | 0.64 | IDO1 (0.68) | MAPTSMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |