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Sugi Predict / Targets / RTN4

RTN4

Reticulon-4 · Q9NQC3 · RTN4 on Sugi Atlas →

2,488 patent compounds predicted against RTN4, 1,777 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL16637284 SCHEMBL16637284 1.00 1/20
SCHEMBL18128690 SCHEMBL18128690 0.93 1/20
SCHEMBL16647182 SCHEMBL16647182 0.88 1/20
SCHEMBL16646915 SCHEMBL16646915 0.84 1/20
SCHEMBL18842314 SCHEMBL18842314 0.83 1/20
SCHEMBL18128425 SCHEMBL18128425 0.82 1/20
SCHEMBL18963672 SCHEMBL18963672 0.81 1/20
SCHEMBL18964390 SCHEMBL18964390 0.81 1/20
SCHEMBL17030812 SCHEMBL17030812 0.80 1/20
SCHEMBL16647110 SCHEMBL16647110 0.80 1/20
SCHEMBL18128369 SCHEMBL18128369 0.80 1/20
SCHEMBL16646906 SCHEMBL16646906 0.80 1/20
SCHEMBL18128738 SCHEMBL18128738 0.79 1/20
SCHEMBL16646901 SCHEMBL16646901 0.79 1/20
SCHEMBL16636979 SCHEMBL16636979 0.78 1/20
SCHEMBL16647071 SCHEMBL16647071 0.78 1/20
SCHEMBL16646882 SCHEMBL16646882 0.77 1/20
SCHEMBL18128620 SCHEMBL18128620 0.77 1/20
SCHEMBL16637403 SCHEMBL16637403 0.77 1/20
SCHEMBL19084490 SCHEMBL19084490 0.76 1/20

Clinical trials — most relevant to RTN4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Effect of Pre-operative Electrical Stimulation on Peripheral Nerve Regeneration. PHASE2/PHASE3COMPLETED
GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS) PHASE2COMPLETED
The Synapse Project PHASE2COMPLETED
Neuromuscular Transmission in Amyotrophic Lateral Sclerosis nanCOMPLETED
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation nanUNKNOWN
Susceptibility Genes in Autism Spectrum Disorders nanCOMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia nanUNKNOWN
Brain Involvement in Dystrophinopathies Part 2 nanCOMPLETED
Exploring the Genetics of Neuropathic Pain nanRECRUITING
Protein Synthesis in the Brain of Patients With Fragile X Syndrome nanCOMPLETED
Nerve Ultrasound in Acquired and Genetic Sensory Neuronopathies nanNOT_YET_RECRUITING
Precision Diagnosis and Therapy for Rare Diseases by Interpreting Non-coding Genomes nanRECRUITING
Speech and Short-term Memory Functions in Dyslexia: a Combined MEG and EEG Study nanUNKNOWN
Biomarker Research in Inherited Movement Disorders nanRECRUITING
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases nanCOMPLETED
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others nanRECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Repeated Bout Effect i Neuromuscular Diseases nanRECRUITING
sCD163 in ALS Patients nanCOMPLETED
B3 for NMD: Bench to Bedside and Back nanENROLLING_BY_INVITATION
LAMA2-related Muscular Dystrophy Brain Study nanWITHDRAWN
Identification of New Genes Implicated in Rare Neurosensory Diseases by Whole Exome Sequencing nanUNKNOWN
Validation of a Prognostic Biomarker Using Brain Diffusion MRI in X-linked Adrenoleukodystrophy nanNOT_YET_RECRUITING
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients nanRECRUITING
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing nanNOT_YET_RECRUITING
Natural History of the Leukodystrophies nanCOMPLETED
Neurotrophin Expression in Infants as a Predictor of Respiratory and Neurodevelopmental Outcomes nanCOMPLETED
Characteristics of Idiopathic Familial Voice Disorders nanCOMPLETED
Identification of New FTLD Genes nanUNKNOWN
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a RTN4 binder may also engage these)

ProteinNameSimilarity
Q99P72 — 1.000 Q99P72 →
Q9JK11 — 1.000 Q9JK11 →
P15146 — 0.994 P15146 →
P20357 — 0.993 P20357 →
Q9VYD1 — 0.992 Q9VYD1 →
ASH1L Histone-lysine N-methyltransferase ASH1L 0.992 landscape →
Q3T0A6 — 0.991 Q3T0A6 →
RTN3 Reticulon-3 0.991 landscape →
Q9W1R4 — 0.991 Q9W1R4 →
Q96JQ2 — 0.991 Q96JQ2 →
MAP2 Microtubule-associated protein 2 0.990 landscape →
Q3ZBP0 — 0.990 Q3ZBP0 →
Q498L0 — 0.990 Q498L0 →
A0MS83 — 0.990 A0MS83 →
Q28DZ0 — 0.990 Q28DZ0 →
O75952 — 0.990 O75952 →
P23226 — 0.989 P23226 →
P70399 — 0.989 P70399 →
Q5S6V2 — 0.989 Q5S6V2 →
Q5H9B9 — 0.989 Q5H9B9 →
P47136 — 0.989 P47136 →
TP53BP1 TP53-binding protein 1 0.989 landscape →
Q9DDD5 — 0.989 Q9DDD5 →
P19332 — 0.988 P19332 →
Q62806 — 0.988 Q62806 →
A7MC64 — 0.988 A7MC64 →
Q6NWJ0 — 0.988 Q6NWJ0 →
Q5M7W5 — 0.988 Q5M7W5 →
Q8L7I1 — 0.988 Q8L7I1 →
Q9JIX8 — 0.988 Q9JIX8 →