SEC16A — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4699731	1.00	2/20
SCHEMBL16111548	1.00	2/20
SCHEMBL29358745	1.00	2/20
SCHEMBL29380618	1.00	2/20
SCHEMBL29931136	1.00	2/20
SCHEMBL4697866	0.89	2/20
SCHEMBL24532075	0.89	2/20
SCHEMBL4697696	0.86	2/20
SCHEMBL23092285	0.86	2/20
SCHEMBL29688472	0.86	2/20
SCHEMBL22024695	0.86	2/20
SCHEMBL16136600	0.84	2/20
SCHEMBL24532058	0.83	2/20
SCHEMBL4699947	0.83	2/20
SCHEMBL22025026	0.82	2/20
SCHEMBL22119546	0.82	2/20
SCHEMBL24532062	0.82	2/20
SCHEMBL18804561	0.81	2/20
SCHEMBL22024561	0.81	2/20
SCHEMBL22025030	0.81	2/20

Clinical trials — most relevant to SEC16A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome)	PHASE2/PHASE3	UNKNOWN
A Study to Evaluate the Efficacy and Safety of Three Fixed Doses of Extended-release Paliperidone in Subjects With Bipolar I Disorder	PHASE3	COMPLETED
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops	PHASE2	UNKNOWN
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
Liraglutide Treatment in Patients With Maturity-onset Diabetes of the Young (MODY)	PHASE2	RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Phase I Study of Novel Estrogen Receptor(ER) a36 Modifier Icaritin in Advanced Breast Cancer Patients	PHASE1	UNKNOWN
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans	nan	UNKNOWN
Quantification of GADD34 Expression in RA	nan	COMPLETED
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment.	nan	ACTIVE_NOT_RECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
sCD163 in ALS Patients	nan	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children	nan	COMPLETED
Human Epilepsy Genetics--Neuronal Migration Disorders Study	nan	RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
Effects of Vitamin D on Health Promotion During Pregnancy and Its Impact on Prematurity-Related Outcome	nan	UNKNOWN
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles	nan	ACTIVE_NOT_RECRUITING
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)	nan	RECRUITING
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a SEC16A binder may also engage these)

Protein	Name	Similarity
E9QAT4	—	0.992	E9QAT4 →
Q3V0A6	—	0.986	Q3V0A6 →
O02665	—	0.984	O02665 →
Q66HC8	—	0.984	Q66HC8 →
B7ZNG4	—	0.983	B7ZNG4 →
Q9NZP6	—	0.983	Q9NZP6 →
E9Q3S4	—	0.983	E9Q3S4 →
E9Q7D5	—	0.983	E9Q7D5 →
Q29106	—	0.981	Q29106 →
Q3URK3	—	0.981	Q3URK3 →
Q5SWP3	—	0.981	Q5SWP3 →
Q5VV67	—	0.981	Q5VV67 →
D3Z1D3	—	0.981	D3Z1D3 →
Q8K4L6	—	0.981	Q8K4L6 →
Q8K4E0	—	0.981	Q8K4E0 →
M0RD54	—	0.981	M0RD54 →
Q6NZN1	—	0.981	Q6NZN1 →
P69284	—	0.980	P69284 →
Q9D7G9	—	0.980	Q9D7G9 →
Q9Z213	—	0.980	Q9Z213 →
P69280	—	0.980	P69280 →
Q12802	—	0.980	Q12802 →
A2AQH4	—	0.979	A2AQH4 →
E9Q286	—	0.979	E9Q286 →
Q5H9F3	—	0.979	Q5H9F3 →
Q0VAV2	—	0.979	Q0VAV2 →
Q6PE65	—	0.979	Q6PE65 →
Q12774	—	0.979	Q12774 →
Q5SW25	—	0.978	Q5SW25 →
Q15583	—	0.978	Q15583 →