SF3B1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Molibresib (SCHEMBL1872390)	1.00	1/20
Molibresib (SCHEMBL12671490)	1.00	1/20
Molibresib (SCHEMBL12966358)	1.00	1/20
SCHEMBL9998851	0.91	1/20
SCHEMBL14756282	0.88	1/20
SCHEMBL15980874	0.88	1/20
SCHEMBL12966165	0.87	1/20
SCHEMBL14756215	0.87	1/20
SCHEMBL14756339	0.87	1/20
SCHEMBL15980861	0.87	1/20
SCHEMBL9998825	0.86	1/20
SCHEMBL15980893	0.86	1/20
SCHEMBL15980803	0.86	1/20
SCHEMBL1874116	0.85	1/20
SCHEMBL12671221	0.85	1/20
SCHEMBL14756021	0.85	1/20
SCHEMBL14756240	0.85	1/20
SCHEMBL14756287	0.85	1/20
SCHEMBL14756335	0.85	1/20
SCHEMBL14756409	0.85	1/20

Clinical trials — most relevant to SF3B1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Valproate and Levocarnitine in Children With Spinal Muscular Atrophy	PHASE3	UNKNOWN
Enzalutamide and Cabazitaxel in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Anastrozole or Fulvestrant in Treating Postmenopausal Patients With Breast Cancer	PHASE2	COMPLETED
Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN	PHASE1	ACTIVE_NOT_RECRUITING
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Biocollection in MyeloDysplastic Syndrome (P-MDS)	nan	RECRUITING
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care	nan	COMPLETED
Molecular Disease Profile of Hematological Malignancies	nan	UNKNOWN
Monitoring Mutational Burden in Low Risk MDS Patients Using Sequential Peripheral Blood Samples	nan	RECRUITING
GENOMED4ALL: Improving MDS Classification and Prognosis by AI	nan	UNKNOWN
SRSF2 Gene Mutation in Patients With t-MDS/AML	nan	COMPLETED
Ferroptosis Study in SF3B1-mutant Myelodysplastic Syndromes (FerMDS)	nan	RECRUITING
Becker Muscular Dystrophy - A Natural History Study to Predict Efficacy of Exon Skipping	nan	UNKNOWN
Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF)	nan	COMPLETED
Prospective Study of Molecular Predictors of Survival in Myelodysplastic Syndromes	nan	COMPLETED
Mesenchymal Stem Cells in NPM1 Mutated Low Risk Acute Myeloid Leukemia: a Study of the Tumor Microenvironment and Its Contribution to the Outcome	nan	COMPLETED
Patient's Derived Organoids for Drug Screening in Glioblastoma	nan	NOT_YET_RECRUITING
Transcriptomes Breast, Ovarian and Leukocyte Hereditary Genes Predisposing to Breast and / or Ovarian Cancer	nan	COMPLETED
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
Genomic Services Research Program	nan	RECRUITING
Prognostic Molecular Markers in Patients With Myelodysplastic Syndrome	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Clinical Study of Spinal Muscular Atrophy	nan	COMPLETED
Outcome Measures and Biomarkers in a Cohort of Spinal Muscular Atrophy Type III/ IV Patients	nan	ACTIVE_NOT_RECRUITING
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Identification and Characterization of Novel Non-Coding Variants That Contribute to Genetic Disorders	nan	COMPLETED
Mechanisms of Cell Death in Spinal Muscular Atrophy	nan	COMPLETED
Studying Gene Expression in Tissue Samples From Young Patients With Acute Myeloid Leukemia	nan	COMPLETED
Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants	nan	RECRUITING
Shwachman Diamond Syndrome Registry and Study	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a SF3B1 binder may also engage these)

Protein	Name	Similarity
Q99NB9	—	1.000	Q99NB9 →
O57683	—	1.000	O57683 →
Q10178	—	0.995	Q10178 →
O54774	—	0.993	O54774 →
J9VXM5	—	0.989	J9VXM5 →
A6RJA2	—	0.989	A6RJA2 →
B3H615	—	0.989	B3H615 →
Q9N3S4	—	0.989	Q9N3S4 →
P54362	—	0.989	P54362 →
P0CR72	—	0.989	P0CR72 →
Q5ASA5	—	0.988	Q5ASA5 →
Q28653	—	0.988	Q28653 →
F4IF36	—	0.988	F4IF36 →
A1ZAJ2	—	0.988	A1ZAJ2 →
B4N0P7	—	0.988	B4N0P7 →
PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.988	landscape →
Q9AWM8	—	0.988	Q9AWM8 →
Q95RG8	—	0.988	Q95RG8 →
AP3D1	AP-3 complex subunit delta-1	0.988	landscape →
A8WVU9	—	0.988	A8WVU9 →
Q23356	—	0.988	Q23356 →
B5X574	—	0.988	B5X574 →
P49583	—	0.988	P49583 →
Q8BH53	—	0.988	Q8BH53 →
Q0IHQ3	—	0.988	Q0IHQ3 →
Q865S1	—	0.987	Q865S1 →
P43125	—	0.987	P43125 →
P38431	—	0.987	P38431 →
Q6QM28	—	0.987	Q6QM28 →
Q9U9K0	—	0.987	Q9U9K0 →