SKIC8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to SKIC8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Genetic Study for Infantile Onset Diabetes Mellitus	nan	UNKNOWN
Genetic Study in Patients With Stage II or Stage III Colon Cancer	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
New Genes in the Carcinogenesis of Colorectal Cancer	nan	UNKNOWN
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Study of Genotype and Phenotype Characterization in Duchenne Muscular Dystrophy With Small Mutations	nan	UNKNOWN
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases	nan	NOT_YET_RECRUITING
Transcripts with Retained H/ACA Box SnoRNA Sequences As Biomarkers for Estrogen Dependence in Lum-B Breast Carcinomas	nan	ACTIVE_NOT_RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Relationship Between Genes Important in Blood Pressure Regulation and Blood Pressure Therapy in Hypertension	nan	COMPLETED
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SKIC8 binder may also engage these)

Protein	Name	Similarity
Q4V7A0	—	1.000	Q4V7A0 →
Q9ERF3	—	1.000	Q9ERF3 →
Q32LN7	—	0.998	Q32LN7 →
Q6PBD6	—	0.998	Q6PBD6 →
Q6P5M2	—	0.998	Q6P5M2 →
Q6GMD2	—	0.997	Q6GMD2 →
Q5ZJH5	—	0.996	Q5ZJH5 →
P41318	—	0.975	P41318 →
Q9AYE4	—	0.966	Q9AYE4 →
O74184	—	0.966	O74184 →
Q93134	—	0.960	Q93134 →
Q9Z1Z2	—	0.960	Q9Z1Z2 →
Q9LV27	—	0.960	Q9LV27 →
Q5E959	—	0.959	Q5E959 →
Q5ZL33	—	0.959	Q5ZL33 →
D4AZ50	—	0.959	D4AZ50 →
Q5XIG8	—	0.958	Q5XIG8 →
B5FZ19	—	0.957	B5FZ19 →
B4KT48	—	0.956	B4KT48 →
STRAP	Serine-threonine kinase receptor-associated protein	0.956	landscape →
Q7KNS3	—	0.955	Q7KNS3 →
A7S338	—	0.955	A7S338 →
Q9FKT5	—	0.955	Q9FKT5 →
B3NPW0	—	0.955	B3NPW0 →
P63247	—	0.955	P63247 →
B4HSL3	—	0.954	B4HSL3 →
B4P6P9	—	0.954	B4P6P9 →
C4Q0P6	—	0.953	C4Q0P6 →
A1CUD6	—	0.953	A1CUD6 →
Q9DAW6	—	0.953	Q9DAW6 →