SLC46A1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1604603	0.72	17/20
SCHEMBL1604705	0.72	17/20
SCHEMBL1604607	0.78	16/20
SCHEMBL1603722	1.00	15/20
SCHEMBL1603726	1.00	15/20
SCHEMBL1604573	1.00	15/20
SCHEMBL1604578	1.00	15/20
SCHEMBL1605463	0.78	15/20
SCHEMBL1604709	0.78	15/20
SCHEMBL1605429	1.00	14/20
SCHEMBL1605437	1.00	14/20
SCHEMBL1604415	0.72	14/20
SCHEMBL1605460	0.72	14/20
SCHEMBL1604587	0.62	14/20
SCHEMBL1604592	0.62	14/20
SCHEMBL1604409	0.54	14/20
SCHEMBL3156359	0.52	14/20
SCHEMBL1605562	0.50	14/20
SCHEMBL1604735	0.49	14/20
SCHEMBL1605557	0.47	14/20

Clinical trials — most relevant to SLC46A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies	PHASE4	COMPLETED
Study Using FolateScan to Identify Subjects With Folate Receptor-Positive Metastatic Renal Cell Carcinoma	PHASE2	COMPLETED
A Placebo-controlled Trial of Folinic Acid in Children With ASD	PHASE2	RECRUITING
A Study Comparing CO-1.01 With Gemcitabine as First Line Therapy in Patients With Metastatic Pancreatic Adenocarcinoma (LEAP)	PHASE2	COMPLETED
10-Propargyl-10-Deazaaminopterin in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma	PHASE1/PHASE2	COMPLETED
Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia	PHASE1/PHASE2	COMPLETED
Trial of Trientine Plus Pegylated Liposomal Doxorubicin and Carboplatin in Epithelial Ovarian Cancer	PHASE1/PHASE2	COMPLETED
Vatalanib and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors	PHASE1	COMPLETED
Intraoperative Imaging of Pulmonary Nodules by OTL38	PHASE1	COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters	EARLY_PHASE1	COMPLETED
Effects of Vitamin D Replacement on Hormones Regulating Iron Metabolism in Individuals With Chronic Kidney Disease	EARLY_PHASE1	COMPLETED
Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I	EARLY_PHASE1	COMPLETED
Assessing Colonic Folate Absorption & Metabolism	nan	UNKNOWN
PK/PD Investigation of Calciumfolinat in Blood, Tumor and Adjacent Mucosa in Patient With Colon Cancer	nan	UNKNOWN
Influence of Iron and Foliate Transporters on Bioavailability of These Micronutrients in the Organism	nan	COMPLETED
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
Response or Resistance to Chemotherapy in Young Patients With Acute Lymphoblastic Leukemia Treated With Methotrexate	nan	COMPLETED
Choroid Plexus Dysfunction in Neurological Diseases	nan	RECRUITING
Genes-in-Action - Hepcidin Regulation of Iron Supplementation	nan	COMPLETED
Mechanism of Decreased Iron Absorption in Obesity: Controlling Adiposity-related Inflammation	nan	COMPLETED
Incidence of Iron Deficiency in Polycythemia Vera (PV) and Association With Disease Features	nan	UNKNOWN
Where is the Initial Site of Biotransformation of Folates in Humans?	nan	COMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Renal and Hepatic Clearance Following High-Dose Methotrexate in Childhood ALL	nan	COMPLETED
Genetic Susceptibility Biomarkers in Children With Neuroblastoma (Also Known as Neuroblastoma Epidemiology in North America [NENA])	nan	COMPLETED
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))	nan	COMPLETED
Biomarker Directed Adjuvant Chemotherapy for Resected Pancreas Cancer	nan	UNKNOWN
Iron Deficiency in Heart Failure Patients	nan	UNKNOWN
DHFR 19 bp Deletion Polymorphism and Folic Acid Utilization	nan	COMPLETED
Role of the ATP7A Transporter in Ovarian Cancer	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC46A1 binder may also engage these)

Protein	Name	Similarity
Q5EBA8	—	1.000	Q5EBA8 →
Q6PEM8	—	0.995	Q6PEM8 →
Q05B81	—	0.992	Q05B81 →
Q7ZWG6	—	0.983	Q7ZWG6 →
F1NJ67	—	0.980	F1NJ67 →
Q6DCX5	—	0.977	Q6DCX5 →
Q501I9	—	0.955	Q501I9 →
Q9D232	—	0.954	Q9D232 →
Q8NA29	—	0.953	Q8NA29 →
Q6ZMD2	—	0.952	Q6ZMD2 →
Q13286	—	0.951	Q13286 →
Q9DA75	—	0.950	Q9DA75 →
Q8CE47	—	0.950	Q8CE47 →
Q8IY34	—	0.950	Q8IY34 →
Q3U481	—	0.950	Q3U481 →
Q6GNV7	—	0.948	Q6GNV7 →
Q61124	—	0.948	Q61124 →
Q6UXD7	—	0.947	Q6UXD7 →
Q80T22	—	0.947	Q80T22 →
Q866G7	—	0.946	Q866G7 →
Q60HH0	—	0.946	Q60HH0 →
Q29611	—	0.946	Q29611 →
Q4V8E5	—	0.945	Q4V8E5 →
Q9JHI3	—	0.945	Q9JHI3 →
Q96ES6	—	0.945	Q96ES6 →
SLC43A3	Equilibrative nucleobase transporter 1	0.944	landscape →
O08966	—	0.944	O08966 →
F1PZV2	—	0.943	F1PZV2 →
Q8BH31	—	0.942	Q8BH31 →
Q5U419	—	0.941	Q5U419 →