Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC46A1 | Q96NT5 | 15/20 | 0.78 |
| ▸ | GART | P22102 | 15/20 | 0.78 |
| ▸ | FOLR1 | P15328 | 15/20 | 0.78 |
| ▸ | FOLR2 | P14207 | 12/20 | 0.78 |
| ▸ | SLC19A1 | P41440 | 6/20 | 0.78 |
| ▸ | ATIC | P31939 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1604419 | 0.99 | GART (0.78) | SLC46A1GARTFOLR1FOLR2SLC19A1 | |
| SCHEMBL1605437 | 0.88 | GART (1.00) | SLC46A1GARTFOLR1FOLR2SLC19A1 | |
| SCHEMBL1605429 | 0.88 | GART (1.00) | SLC46A1GARTFOLR1FOLR2SLC19A1 | |
| SCHEMBL1604607 | 0.88 | SLC46A1 (0.78) | SLC46A1GARTFOLR1FOLR2SLC19A1 | |
| SCHEMBL3161202 | 0.88 | FOLR1 (0.78) | SLC46A1GARTFOLR1FOLR2SLC19A1 | |
| SCHEMBL1604546 | 0.86 | FOLR1 (0.58) | SLC46A1GARTFOLR1FOLR2SLC19A1 | |
| SCHEMBL1603940 | 0.86 | GART (1.00) | SLC46A1GARTFOLR1FOLR2SLC19A1 | |
| SCHEMBL1603944 | 0.86 | GART (1.00) | SLC46A1GARTFOLR1FOLR2SLC19A1 | |
| SCHEMBL3159773 | 0.86 | FOLR1 (0.78) | SLC46A1GARTFOLR1FOLR2SLC19A1 | |
| SCHEMBL1604709 | 0.86 | GART (0.78) | SLC46A1GARTFOLR1FOLR2SLC19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, FOLR2, FOLR1 | SLC46A1 1/4885GART 22/4885FOLR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.