SLC9A2

Sodium/hydrogen exchanger 2 · Q9UBY0 · SLC9A2 on Sugi Atlas →

2,555 patent compounds predicted against SLC9A2, 1,862 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4450211	0.69	5/20
Hydrochloric Acid (SCHEMBL6312006)	0.66	5/20
SCHEMBL3791701	0.60	5/20
Hydrochloric Acid (SCHEMBL6313304)	0.59	5/20
SCHEMBL3721085	0.56	5/20
Hydrochloric Acid (SCHEMBL6311626)	0.55	5/20
Hydrochloric Acid (SCHEMBL6319044)	0.53	5/20
SCHEMBL6218848	0.48	5/20
Zoniporide (SCHEMBL611159)	1.00	4/20
SCHEMBL4452219	1.00	4/20
SCHEMBL6314103	1.00	4/20
Zoniporide (SCHEMBL6260017)	0.98	4/20
Zoniporide (SCHEMBL6313043)	0.98	4/20
Hydrochloric Acid (SCHEMBL6312415)	0.97	4/20
Zoniporide (SCHEMBL6263288)	0.96	4/20
SCHEMBL4456220	0.86	4/20
Hydrochloric Acid (SCHEMBL6315017)	0.85	4/20
Hydrochloric Acid (SCHEMBL6315561)	0.73	4/20
SCHEMBL4451940	0.73	4/20
SCHEMBL3711215	0.72	4/20

Clinical trials — most relevant to SLC9A2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of the Use of Dapagliflozin in Patients With Refractory Heart Failure	PHASE4	RECRUITING
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study	PHASE4	RECRUITING
SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation.	PHASE4	COMPLETED
Efficacy and Safety of Tigerase® vs. Pulmozyme® in Patients With Cystic Fibrosis	PHASE3	COMPLETED
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
Secretin in Ex-situ Liver Perfusion	PHASE1/PHASE2	ENROLLING_BY_INVITATION
Empagliflozin as a Modulator of Systemic Vascular Resistance and Cardiac Output in Patients With Type 2 Diabetes	PHASE2	COMPLETED
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops	PHASE2	UNKNOWN
Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia	PHASE1/PHASE2	COMPLETED
Empagliflozin in ESKD - A Feasibility Study	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis	EARLY_PHASE1	RECRUITING
Gene Expression in Inflammatory Bowel Disease	nan	ENROLLING_BY_INVITATION
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS	nan	NOT_YET_RECRUITING
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Healthy Humans.	nan	COMPLETED
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS	nan	COMPLETED
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
SLC13A5 Deficiency Natural History Study - United States Only	nan	ENROLLING_BY_INVITATION
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
New Biomarkers and Difficult-to-treat Hypertension	nan	COMPLETED
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Cardiovascular Effects of Empagliflozine	nan	UNKNOWN
Central Sodium Sensing: Implications for Blood Pressure Regulation	nan	COMPLETED
Adverse Airway Effects From Tobacco and E-Cigarettes	nan	UNKNOWN
Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease	nan	COMPLETED
Blood Pressure Control in Juveniles - Longitudinal Study	nan	COMPLETED
Impact of Sodium Glucose Co-transporter 2-Inhibitors on Clinical Outcome and Left Ventricular Function in Patients Presented by Acute Myocardial Infarction	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC9A2 binder may also engage these)

Protein	Name	Similarity
P48763	—	1.000	P48763 →
P50482	—	1.000	P50482 →
Q3ZAS0	—	1.000	Q3ZAS0 →
P48761	—	1.000	P48761 →
SLC9A1	Sodium/hydrogen exchanger 1	0.999	landscape →
Q28036	—	0.998	Q28036 →
P48762	—	0.997	P48762 →
Q61165	—	0.995	Q61165 →
Q01345	—	0.995	Q01345 →
P26431	—	0.994	P26431 →
P23791	—	0.994	P23791 →
Q96T83	—	0.994	Q96T83 →
Q6AI14	—	0.993	Q6AI14 →
A1L3P4	—	0.992	A1L3P4 →
D3ZJ86	—	0.992	D3ZJ86 →
P26434	—	0.992	P26434 →
Q8BUE1	—	0.992	Q8BUE1 →
D4A7H1	—	0.991	D4A7H1 →
Q8BLV3	—	0.990	Q8BLV3 →
Q92581	—	0.988	Q92581 →
F7B113	—	0.986	F7B113 →
P35449	—	0.984	P35449 →
Q8IVB4	—	0.983	Q8IVB4 →
Q8BZ00	—	0.982	Q8BZ00 →
O16452	—	0.981	O16452 →
SLC9A3	Sodium/hydrogen exchanger 3	0.979	landscape →
Q28362	—	0.976	Q28362 →
P26432	—	0.974	P26432 →
Q9IAL8	—	0.974	Q9IAL8 →
G3X939	—	0.974	G3X939 →