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SMC2

Structural maintenance of chromosomes protein 2 · O95347 · SMC2 on Sugi Atlas →

1,512 patent compounds predicted against SMC2, 1,166 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Selumetinib Selumetinib (SCHEMBL155456) 1.00 1/20
Gsk-690693 Gsk-690693 (SCHEMBL310452) 1.00 1/20
Gsk-690693 Gsk-690693 (SCHEMBL2195376) 1.00 1/20
Selumetinib Selumetinib (SCHEMBL2354340) 0.94 1/20
SCHEMBL3487696 SCHEMBL3487696 0.92 1/20
SCHEMBL4546029 SCHEMBL4546029 0.91 1/20
SCHEMBL4546010 SCHEMBL4546010 0.87 1/20
SCHEMBL1038067 SCHEMBL1038067 0.85 1/20
SCHEMBL4545997 SCHEMBL4545997 0.85 1/20
SCHEMBL569289 SCHEMBL569289 0.84 1/20
Binimetinib Binimetinib (SCHEMBL570088) 0.84 1/20
SCHEMBL1037416 SCHEMBL1037416 0.84 1/20
SCHEMBL10053680 SCHEMBL10053680 0.84 1/20
SCHEMBL4545993 SCHEMBL4545993 0.83 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL690160) 0.82 1/20
SCHEMBL1077790 SCHEMBL1077790 0.82 1/20
SCHEMBL2877129 SCHEMBL2877129 0.82 1/20
SCHEMBL4546015 SCHEMBL4546015 0.82 1/20
SCHEMBL4546033 SCHEMBL4546033 0.82 1/20
SCHEMBL4546036 SCHEMBL4546036 0.82 1/20

Clinical trials — most relevant to SMC2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment PHASE2/PHASE3RECRUITING
Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients PHASE3UNKNOWN
Neoadjuvant Camrelizumab and Fluzoparib and Nab-paclitaxel in Early Breast Cancer With HRR Gene Mutation PHASE2RECRUITING
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma PHASE1/PHASE2COMPLETED
Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma PHASE1UNKNOWN
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome PHASE1COMPLETED
Evaluation of the Safety and the Tolerability of a Combination of Two HIV Inducers in Patients With Undetectable Viral Load PHASE1COMPLETED
Imetelstat for Children With Refractory or Recurrent Solid Tumors and Lymphoma PHASE1WITHDRAWN
Talazoparib for Cohesin-Mutated AML and MDS With Excess Blasts PHASE1ACTIVE_NOT_RECRUITING
Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas PHASE1COMPLETED
Proteomic-Based Profiling of Lymphomas: Chromatin Proteomics; Composition and Modification of Histone and Non-Histone Chromosomal Proteins nanCOMPLETED
Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility nanCOMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients nanRECRUITING
Immunophenotyping and Xist Gene in AML nanUNKNOWN
Telomeric Abnormalities in Colorectal Diseases by Fluorescent in Situ Hybridization Technique nanUNKNOWN
Mesenchymal Stem Cells in NPM1 Mutated Low Risk Acute Myeloid Leukemia: a Study of the Tumor Microenvironment and Its Contribution to the Outcome nanCOMPLETED
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility nanRECRUITING
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia nanUNKNOWN
Chromosome 18 Clinical Research Center nanRECRUITING
Telomeres Length in Israeli Fibrotic ILD Patients nanENROLLING_BY_INVITATION
The Contribution of Optical Mapping to the Characterization of Chromosomal Rearrangements in Patients With Neurodevelopmental Disorders nanRECRUITING
DNA Analysis From Isolated Cardiomyocytes in the Molecular Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia nanCOMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact nanUNKNOWN
Genetic of SportS Induced Endofibrotic Remodeling nanCOMPLETED
Impact of Weight Loss on the Human Sperm Epitranscriptome nanACTIVE_NOT_RECRUITING
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Nasal Brushing for the Diagnosis and Understanding of Telomeropathies nanUNKNOWN
Aerobic Exercise and Telomere Length in Patients With Heart Failure. nanUNKNOWN
Collaborative Studies on the Genetics of Asthma (CSGA) nanCOMPLETED
DNA Methylation and Autoimmune Thyroid Diseases nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SMC2 binder may also engage these)

ProteinNameSimilarity
Q8CG48 — 1.000 Q8CG48 →
Q9C5Y4 — 1.000 Q9C5Y4 →
Q90988 — 1.000 Q90988 →
Q9SN90 — 1.000 Q9SN90 →
P50533 — 1.000 P50533 →
Q54PK4 — 0.999 Q54PK4 →
Q802R8 — 0.993 Q802R8 →
P70388 — 0.992 P70388 →
Q9FJL0 — 0.992 Q9FJL0 →
Q9JIL8 — 0.992 Q9JIL8 →
P41003 — 0.992 P41003 →
Q924W5 — 0.992 Q924W5 →
Q6Q1P4 — 0.992 Q6Q1P4 →
Q9CW03 — 0.992 Q9CW03 →
SMC3 Structural maintenance of chromosomes protein 3 0.992 landscape →
Q9FLR5 — 0.991 Q9FLR5 →
RAD50 DNA repair protein RAD50 0.991 landscape →
A0A1L8GXM0 — 0.991 A0A1L8GXM0 →
Q96SB8 — 0.990 Q96SB8 →
O01789 — 0.990 O01789 →
P38989 — 0.990 P38989 →
O93309 — 0.990 O93309 →
Q6P9I7 — 0.989 Q6P9I7 →
Q9SL02 — 0.989 Q9SL02 →
Q9FII7 — 0.989 Q9FII7 →
B2FDA8 — 0.989 B2FDA8 →
Q5R4K5 — 0.989 Q5R4K5 →
Q8NDV3 — 0.987 Q8NDV3 →
Q54LV0 — 0.986 Q54LV0 →
O97594 — 0.986 O97594 →