SNAP23 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4699731	1.00	2/20
SCHEMBL16111548	1.00	2/20
SCHEMBL29358745	1.00	2/20
SCHEMBL29380618	1.00	2/20
SCHEMBL29931136	1.00	2/20
SCHEMBL4697866	0.89	2/20
SCHEMBL24532075	0.89	2/20
SCHEMBL4697696	0.86	2/20
SCHEMBL23092285	0.86	2/20
SCHEMBL29688472	0.86	2/20
SCHEMBL22024695	0.86	2/20
SCHEMBL16136600	0.84	2/20
SCHEMBL24532058	0.83	2/20
SCHEMBL4699947	0.83	2/20
SCHEMBL22025026	0.82	2/20
SCHEMBL22119546	0.82	2/20
SCHEMBL24532062	0.82	2/20
SCHEMBL18804561	0.81	2/20
SCHEMBL22024561	0.81	2/20
SCHEMBL22025030	0.81	2/20

Clinical trials — most relevant to SNAP23 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Ketamine Treatment Effects on Synaptic Plasticity in Depression	PHASE4	COMPLETED
The Synapse Project	PHASE2	COMPLETED
A Study to Assess the Safety of BMS-984923 Compared to Placebo, in People With Parkinson's	PHASE1	UNKNOWN
Changes in Glutamatergic Neurotransmission of Severe TBI Patients	EARLY_PHASE1	SUSPENDED
Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy	EARLY_PHASE1	ACTIVE_NOT_RECRUITING
Combined Aerobic Exercise and Cognitive Training in Seniors at Increased Risk for Alzheimer's Disease	nan	NOT_YET_RECRUITING
Multicenter Study of Patients With SHANK3 Mutations: Identification of Genes Modificators in Phelan-McDermid Syndrome (EUQ13)	nan	NOT_YET_RECRUITING
Toward Molecular Profiling of Parkinson's Disease in Easily Accessible Biological Matrices	nan	ACTIVE_NOT_RECRUITING
Study of the Genetic Factors Involved in Autism and Related Disorders	nan	RECRUITING
Synaptic Injury and Functional Connectivity in Alzheimer's Disease	nan	COMPLETED
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort	nan	RECRUITING
Neurophysiologic Biomarkers in Rett Syndrome	nan	RECRUITING
Baker Gordon Syndrome Natural History Study	nan	RECRUITING
miR-142-3p as Potential Biomarker of Synaptopathy in MS	nan	UNKNOWN
Q10 Ubiquinol in Autism Spectrum Disorder and in Phelan-McDermid Syndrome.	nan	UNKNOWN
Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs.	nan	ENROLLING_BY_INVITATION
Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging	nan	NOT_YET_RECRUITING
Efficacy of Probiotics for Parkinson Disease (PD)	nan	WITHDRAWN
A Study on Psychopathological Progress of Early Schizophrenia-Like Disorder (SOPRES)	nan	UNKNOWN
STXBP1 and SYNGAP1 Related Disorders Natural History Study	nan	RECRUITING
Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for Precursor Biomarker for Neurodegeneration	nan	COMPLETED
Progression Follow up of the First-degree Relatives of Patients With REM Sleep Behavior Disorder	nan	UNKNOWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Susceptibility Genes in Autism Spectrum Disorders	nan	COMPLETED
Serum Biomarkers in Parkinson's Disease at Different Stages	nan	RECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder.	nan	UNKNOWN
Sensorimotor Gating in Schizophrenia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SNAP23 binder may also engage these)

Protein	Name	Similarity
O70377	—	0.993	O70377 →
P36976	—	0.990	P36976 →
O09044	—	0.989	O09044 →
Q0E1I7	—	0.973	Q0E1I7 →
P36975	—	0.972	P36975 →
SNAP29	Synaptosomal-associated protein 29	0.970	landscape →
Q9LMG8	—	0.967	Q9LMG8 →
Q5R5K4	—	0.966	Q5R5K4 →
Q9SD96	—	0.966	Q9SD96 →
Q9S7P9	—	0.965	Q9S7P9 →
Q9ERB0	—	0.965	Q9ERB0 →
Q9Z2P6	—	0.965	Q9Z2P6 →
Q6PC54	—	0.963	Q6PC54 →
P36978	—	0.960	P36978 →
P58200	—	0.960	P58200 →
Q0II86	—	0.958	Q0II86 →
Q9LRP1	—	0.955	Q9LRP1 →
Q944A9	—	0.954	Q944A9 →
Q9UEU0	—	0.953	Q9UEU0 →
Q9SRV7	—	0.952	Q9SRV7 →
Q2KIU0	—	0.951	Q2KIU0 →
Q9LNH6	—	0.951	Q9LNH6 →
P83528	—	0.950	P83528 →
P83351	—	0.950	P83351 →
Q7XIE2	—	0.950	Q7XIE2 →
P61265	—	0.949	P61265 →
P61266	—	0.949	P61266 →
Q9ZPV9	—	0.949	Q9ZPV9 →
P61267	—	0.949	P61267 →
O70439	—	0.948	O70439 →