TCOF1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to TCOF1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa	PHASE1	COMPLETED
Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to Phenotype	EARLY_PHASE1	COMPLETED
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Diagnosis of Primary Ciliary Dyskinesia	nan	COMPLETED
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism	nan	COMPLETED
Proteomic Study of Tears From Patients With a PAX6 Mutation	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions	nan	RECRUITING
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Genetics of Primary Ciliary Dyskinesia	nan	COMPLETED
Genetic Diagnosis in Congenital Cataracts	nan	COMPLETED
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Pathogenetic Basis of Aortopathy and Aortic Valve Disease	nan	ACTIVE_NOT_RECRUITING
Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Gyrate Atrophy Ocular and Systemic Study	nan	ACTIVE_NOT_RECRUITING
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
A Two-Part Multicenter Prospective Longitudinal Study of CFTR-dependent Disease Profiling in Cystic Fibrosis (PROSPECT)	nan	COMPLETED
Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial	nan	COMPLETED
Respiratory Registry for Lung Health: a Prospective, Observational Study on Adult Patients With Asthma or COPD	nan	UNKNOWN
Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy	nan	COMPLETED
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Monogenic Diabetes Misdiagnosed as Type 1	nan	RECRUITING
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a TCOF1 binder may also engage these)

Protein	Name	Similarity
O08784	—	0.995	O08784 →
Q8N1P7	—	0.981	Q8N1P7 →
Q3UNH4	—	0.981	Q3UNH4 →
Q7Z2K8	—	0.979	Q7Z2K8 →
Q8N3D4	—	0.978	Q8N3D4 →
Q63560	—	0.976	Q63560 →
Q5TM68	—	0.975	Q5TM68 →
MDC1	Mediator of DNA damage checkpoint protein 1	0.975	landscape →
Q9PU53	—	0.975	Q9PU53 →
Q7TSJ2	—	0.975	Q7TSJ2 →
Q7YR40	—	0.975	Q7YR40 →
Q4R729	—	0.974	Q4R729 →
P24587	—	0.973	P24587 →
A4FU49	—	0.972	A4FU49 →
Q767L8	—	0.972	Q767L8 →
Q96JE9	—	0.972	Q96JE9 →
Q5TM66	—	0.971	Q5TM66 →
NOLC1	Nucleolar and coiled-body phosphoprotein 1	0.971	landscape →
POLR1G	DNA-directed RNA polymerase I subunit RPA34	0.971	landscape →
Q96QH2	—	0.971	Q96QH2 →
O88737	—	0.971	O88737 →
Q99MS7	—	0.970	Q99MS7 →
A5D7L8	—	0.970	A5D7L8 →
Q8IVF2	—	0.970	Q8IVF2 →
MAP4	Microtubule-associated protein 4	0.970	landscape →
Q5M7W5	—	0.969	Q5M7W5 →
P36225	—	0.969	P36225 →
Q767M0	—	0.969	Q767M0 →
Q9JL04	—	0.969	Q9JL04 →
Q8CJI4	—	0.969	Q8CJI4 →