TGM6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1873625	0.70	2/20
SCHEMBL14053815	0.64	2/20
SCHEMBL14054348	0.63	2/20
SCHEMBL14054350	0.61	2/20
SCHEMBL14055106	0.60	2/20
SCHEMBL14055117	0.59	2/20
SCHEMBL14055346	0.59	2/20
SCHEMBL14054295	0.58	2/20
SCHEMBL1870961	0.57	2/20
SCHEMBL14054176	0.57	2/20
SCHEMBL14055421	0.57	2/20
SCHEMBL14055258	0.56	2/20
SCHEMBL14054012	0.56	2/20
SCHEMBL14054960	0.55	2/20
SCHEMBL14054557	0.54	2/20
SCHEMBL14055204	0.54	2/20
SCHEMBL14054349	0.53	2/20
SCHEMBL14054560	0.52	2/20
SCHEMBL14054940	0.52	2/20
SCHEMBL14054163	0.52	2/20

Clinical trials — most relevant to TGM6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Comparing the Effects of Vitamin E, Ursodeoxycholic Acid and Pentoxyfylline on Egyptian Non-alcoholic Steatohepatitis (NASH) Patients	PHASE4	COMPLETED
Bioequivalence of Two Formulations of Meropenem Intravenous Injection	PHASE4	COMPLETED
SGM-101 in Locally Advanced and Recurrent Rectal Cancer	PHASE2/PHASE3	UNKNOWN
A Study of Lanadelumab to Prevent Hereditary Angioedema (HAE) Attacks in Children	PHASE3	COMPLETED
Phase 2a Study of HU6 in Subjects With Elevated Liver Fat and High BMI Volunteers	PHASE2	COMPLETED
A Study to Evaluate the Safety, Tolerability, and Efficacy of TML-6 in Participants With Early Alzheimer's Disease	PHASE2	NOT_YET_RECRUITING
First-in-human Study of UX016 in GNEM	PHASE1/PHASE2	NOT_YET_RECRUITING
SGM-101 in Colorectal Brain Metastases.	PHASE2	UNKNOWN
SGM-101 in Colorectal Lung Metastases	PHASE2	UNKNOWN
A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory Colorectal Cancer	PHASE1/PHASE2	COMPLETED
Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic	PHASE2	ACTIVE_NOT_RECRUITING
Magrolimab Plus Intensive Chemotherapy in Newly Diagnosed AML or HR-MDS	PHASE2	WITHDRAWN
Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instability	PHASE2	ACTIVE_NOT_RECRUITING
A Study of HS-20136-2 in Healthy Participants	PHASE1	NOT_YET_RECRUITING
BTK Inhibitor DTRMWXHS-12 in Mantle Cell Lymphoma	PHASE1	COMPLETED
Tolerability of Enteral NAC in Infants	PHASE1	NOT_YET_RECRUITING
A Study of RGLS4326 in Patients With Autosomal Dominant Polycystic Kidney Disease	PHASE1	COMPLETED
A Study in Healthy People to Compare How 2 Different Formulations of Survodutide Are Taken up in the Body	PHASE1	COMPLETED
Study to Assess CMR316 in Healthy Volunteers and Patients With Idiopathic Pulmonary Fibrosis	PHASE1	RECRUITING
A Study of MCARH109 and MCARH125 in People With Multiple Myeloma	PHASE1	ACTIVE_NOT_RECRUITING
A Study to Test Whether Multiple Doses of BI 456906 Have an Effect on Cardiac Safety in People With Overweight or Obesity	PHASE1	COMPLETED
Effect of Rosmarinus Officinalis Extract on Oxidative Stress and Inflammatory Biomarkers in Patients With Type 2 Diabetes(T2DM)	PHASE1	ACTIVE_NOT_RECRUITING
A Randomized, Double-blind, Study to Explore the Effect of GED-0301 in Subjects With Active Crohn's Disease	PHASE1	COMPLETED
Canavan-Single Patient IND	nan	NO_LONGER_AVAILABLE
Mediterranean Lifestyle Intervention in Patients With Non-alcoholic Fatty Liver Disease	nan	COMPLETED
Relation Between Carotid Atheroscerosis With DM &Fatty Liver	nan	UNKNOWN
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Granule	nan	UNKNOWN
a Single-arm, Single-center, Open Clinical Study	nan	RECRUITING
Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol	nan	COMPLETED
A Study to Assess the Genetic Variations in Bile Flow Disorders: Linking Progressive Familial Intrahepatic Cholestasis (PFIC)-Related Genes to Symptoms in Adults With Recurrent Cholestasis in Spain	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a TGM6 binder may also engage these)

Protein	Name	Similarity
P51176	—	0.997	P51176 →
Q9D7I9	—	0.995	Q9D7I9 →
P16452	—	0.994	P16452 →
P08587	—	0.994	P08587 →
P21981	—	0.992	P21981 →
Q01841	—	0.992	Q01841 →
Q96PF1	—	0.990	Q96PF1 →
A6QP57	—	0.990	A6QP57 →
P49222	—	0.987	P49222 →
O46510	—	0.987	O46510 →
O43548	—	0.987	O43548 →
P52181	—	0.986	P52181 →
Q5R8R3	—	0.985	Q5R8R3 →
D4A5U3	—	0.985	D4A5U3 →
Q8BG22	—	0.982	Q8BG22 →
A5PJN5	—	0.981	A5PJN5 →
Q9WVJ6	—	0.981	Q9WVJ6 →
TGM2	Protein-glutamine gamma-glutamyltransferase	0.981	landscape →
Q29052	—	0.978	Q29052 →
Q9GLK0	—	0.977	Q9GLK0 →
Q8VDP3	—	0.977	Q8VDP3 →
Q149M9	—	0.977	Q149M9 →
O55171	—	0.977	O55171 →
Q08189	—	0.976	Q08189 →
Q9Y4C2	—	0.976	Q9Y4C2 →
Q05187	—	0.976	Q05187 →
D3ZBP4	—	0.976	D3ZBP4 →
Q6NTR1	—	0.975	Q6NTR1 →
A2VE29	—	0.975	A2VE29 →
Q8BH61	—	0.975	Q8BH61 →