Sugi Predict

Sugi Predict / Targets / TKFC

TKFC

Triokinase/FMN cyclase · Q3LXA3 · TKFC on Sugi Atlas →

0 patent compounds predicted against TKFC, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to TKFC by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia PHASE2/PHASE3UNKNOWN
Preventing Acute Kidney Injury (AKI) in Pediatric Patients PHASE3UNKNOWN
Methylene Blue and Microcirculation in Septic Shock PHASE3UNKNOWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals PHASE1/PHASE2COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia PHASE1/PHASE2COMPLETED
Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm PHASE2WITHDRAWN
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC PHASE2COMPLETED
Sorafenib and Bevacizumab to Treat Ovarian, Fallopian and Peritoneal Cancer PHASE2COMPLETED
Biological Effects of Quercetin in COPD Phase II PHASE2UNKNOWN
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE PHASE2UNKNOWN
SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients PHASE1/PHASE2COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults PHASE1RECRUITING
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL EARLY_PHASE1UNKNOWN
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models nanCOMPLETED
NCF Gene & TNFSF4 in SLE Patients nanUNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart nanUNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. nanCOMPLETED
Correlation Between EGFR Mutation Using cfDNAs and Circulating Tumor Cells in Patients With NSCLC nanUNKNOWN
Exome Analysis in Hearing Impaired Patients nanUNKNOWN
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing nanCOMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
A Retrospective Study to Determine the Incidence of NTRK Fusions. NTRK Study nanCOMPLETED
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
The Safety and Efficacy Study of RiaGev in Healthy Adults nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TKFC binder may also engage these)

ProteinNameSimilarity
F1RKQ4 — 0.999 F1RKQ4 →
Q4KLZ6 — 0.999 Q4KLZ6 →
Q58DK4 — 0.997 Q58DK4 →
Q8VC30 — 0.995 Q8VC30 →
Q5EAD2 — 0.973 Q5EAD2 →
A5GFY8 — 0.973 A5GFY8 →
Q08BL7 — 0.972 Q08BL7 →
Q9YH58 — 0.971 Q9YH58 →
Q59A32 — 0.971 Q59A32 →
Q5RBT4 — 0.970 Q5RBT4 →
Q64737 — 0.970 Q64737 →
Q8RZA1 — 0.970 Q8RZA1 →
Q28479 — 0.970 Q28479 →
Q9HAB8 — 0.970 Q9HAB8 →
P51855 — 0.969 P51855 →
GART Trifunctional purine biosynthetic protein adenosine-3 0.969 landscape →
Q68FX0 — 0.969 Q68FX0 →
P46413 — 0.968 P46413 →
Q61753 — 0.968 Q61753 →
O08651 — 0.968 O08651 →
Q9LDN2 — 0.968 Q9LDN2 →
GSS Glutathione synthetase 0.968 landscape →
Q0J7N5 — 0.967 Q0J7N5 →
P21872 — 0.967 P21872 →
O60027 — 0.967 O60027 →
Q8CFX8 — 0.966 Q8CFX8 →
Q60HD7 — 0.966 Q60HD7 →
Q9BE01 — 0.966 Q9BE01 →
Q5R7M2 — 0.966 Q5R7M2 →
PHGDH D-3-phosphoglycerate dehydrogenase 0.966 landscape →