TMCO1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to TMCO1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
COMS for Chronic Ulcers Treatment	PHASE4	RECRUITING
Does Treatment of Hypovitaminosis D Increase Calcium Absorption?	PHASE4	COMPLETED
Magnesium Administration in Liver Transplantation and Reperfusion Injury	PHASE4	COMPLETED
Levosimendan in Acute Decompensated Heart Failure	PHASE2/PHASE3	NOT_YET_RECRUITING
Role of Intralipid in Management of Organophosphorus Poisoning	PHASE2/PHASE3	WITHDRAWN
Magnesium in Coronaries (MAGIC)	PHASE3	COMPLETED
Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem	PHASE2/PHASE3	COMPLETED
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators.	PHASE2	NOT_YET_RECRUITING
A Phase I/II, First-In-Human Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Activity to Prevent or Treat Neuropsychiatric Symptoms in Pediatric Subjects With Timothy Syndrome	PHASE1/PHASE2	NOT_YET_RECRUITING
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Calcium Channel Blockade in Primary Aldosteronism	PHASE2	COMPLETED
Antioxidant Therapy in RYR1-Related Congenital Myopathy	PHASE1/PHASE2	COMPLETED
S 48168 (ARM 210) for the Treatment of RYR1-related Myopathies (RYR1-RM)	PHASE1	COMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure	nan	UNKNOWN
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)	nan	COMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors	nan	UNKNOWN
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development	nan	RECRUITING
Effects of Fos Biomedical Device on Diabetes Risk Factors and Sleep Quality in Adults at Risk for Type 2 Diabetes	nan	COMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis	nan	UNKNOWN
The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity	nan	WITHDRAWN
Evaluation of A Clinical Diagnostic Test for CRDS	nan	RECRUITING
Left Atrial Appendage Occlusion Study III Extended Follow Up	nan	WITHDRAWN
The Prevalence of RYR1-related Disease	nan	NOT_YET_RECRUITING
International CRDS Registry	nan	RECRUITING
Tart Cherry Juice for Exercise Performance and Recovery	nan	COMPLETED
Sevoflurane Effect on Left Atrial Performance: A Transoesophageal Echocardiographic Study	nan	COMPLETED
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Carnosine Supplementation on Quantity/Quality of Oral Salivae.	nan	UNKNOWN
Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TMCO1 binder may also engage these)

Protein	Name	Similarity
A0A8I3PI99	—	0.958	A0A8I3PI99 →
Q921L3	—	0.955	Q921L3 →
Q5I0H4	—	0.954	Q5I0H4 →
Q3T0N3	—	0.954	Q3T0N3 →
Q00PJ0	—	0.953	Q00PJ0 →
A0M8S0	—	0.952	A0M8S0 →
C5HGF3	—	0.952	C5HGF3 →
A4D7R9	—	0.952	A4D7R9 →
Q07DY8	—	0.951	Q07DY8 →
Q2IBA8	—	0.951	Q2IBA8 →
Q5R9B0	—	0.951	Q5R9B0 →
Q09YH4	—	0.949	Q09YH4 →
Q5XIK2	—	0.948	Q5XIK2 →
Q2QLE8	—	0.948	Q2QLE8 →
Q6DGW9	—	0.948	Q6DGW9 →
Q8VHE0	—	0.948	Q8VHE0 →
Q2IBD0	—	0.947	Q2IBD0 →
Q2QLG2	—	0.947	Q2QLG2 →
Q07DX8	—	0.947	Q07DX8 →
Q4R5B4	—	0.946	Q4R5B4 →
Q09YN2	—	0.946	Q09YN2 →
Q108U3	—	0.946	Q108U3 →
Q8CB44	—	0.946	Q8CB44 →
Q5SWU9	—	0.946	Q5SWU9 →
A4QNE0	—	0.945	A4QNE0 →
Q2KJ46	—	0.945	Q2KJ46 →
Q09YI5	—	0.945	Q09YI5 →
Q2QLD7	—	0.945	Q2QLD7 →
ACACA	Acetyl-CoA carboxylase 1	0.945	landscape →
Q2QLA6	—	0.945	Q2QLA6 →