TMED2

Transmembrane emp24 domain-containing protein 2

0 patent compounds predicted against TMED2, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Germline variants in TMED2 on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full TMED2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to TMED2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
IMA910 Plus GM-CSF With Low-dose Cyclophosphamide Pre-treatment in Advanced Colorectal Carcinoma Patients Following a Successful 12 Week First-line Treatment With Oxaliplatin-based Chemotherapy (IMA910-101)	PHASE1/PHASE2	COMPLETED
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma	PHASE2	RECRUITING
Phase I Study of Novel Estrogen Receptor(ER) a36 Modifier Icaritin in Advanced Breast Cancer Patients	PHASE1	UNKNOWN
Evaluation of Serum Tumor Endothelial Marker1 as a Potential Biomarker for Colorectal Cancer Diagnosis and Cancer Progression	nan	NOT_YET_RECRUITING
Immunophenotypic Evaluation of CD305 and CD85d in B-Cell Lymphoid Neoplasms	nan	NOT_YET_RECRUITING
Clinical Application of PET Imaging Targeting GPA33 in Malignant Tumors	nan	NOT_YET_RECRUITING
Evaluation of CEMIP in Pancreatic Cancer	nan	UNKNOWN
Genome Environment Microbiome and Metabolome in Autism Study	nan	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
FAP PET/CT or PET/MR Production in the Diagnosis, Staging, and Efficacy Assessment of Malignant Tumors Application	nan	COMPLETED
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Study of the Genetic Factors Involved in Autism and Related Disorders	nan	RECRUITING
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Cell Free Circulating Nucleic Acids as New Tumor Diagnostics From Human Plasma Samples.	nan	UNKNOWN
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA	nan	RECRUITING
Pathophysiology of Paget's Disease of Bone	nan	COMPLETED
The Role of Programmed Death Ligand -1 (Pdl-1) in Lung Cancer	nan	COMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
Immune Cell Response to Stimuli	nan	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia	nan	RECRUITING
The Etiology and Progression of Brain Tumors	nan	COMPLETED
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Detection of Circulating Biomarkers of Immunogenic Cell Death	nan	COMPLETED
Study on the Mechanism of ADC Drug Evaluation Based on Immune Co-culture of Lung Cancer Organoids	nan	RECRUITING
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a TMED2 binder may also engage these)

Protein	Name	Similarity
Q63524	—	1.000	Q63524 →
Q9R0Q3	—	1.000	Q9R0Q3 →
P49020	—	1.000	P49020 →
ERGIC1	Endoplasmic reticulum-Golgi intermediate compartment protein 1	0.924	landscape →
Q9DC16	—	0.922	Q9DC16 →
TMED7	Transmembrane emp24 domain-containing protein 7	0.918	landscape →
D3ZTX0	—	0.916	D3ZTX0 →
P62311	—	0.908	P62311 →
P62310	—	0.908	P62310 →
Q2KJ81	—	0.908	Q2KJ81 →
P23438	—	0.907	P23438 →
AP1M1	AP-1 complex subunit mu-1	0.907	landscape →
Q32PE9	—	0.906	Q32PE9 →
GABBR1	Gamma-aminobutyric acid type B receptor subunit 1	0.905	landscape →
Q32Q06	—	0.904	Q32Q06 →
Q5E9E4	—	0.903	Q5E9E4 →
Q9WV18	—	0.902	Q9WV18 →
Q9Z0U4	—	0.902	Q9Z0U4 →
Q13888	—	0.902	Q13888 →
Q2KHU8	—	0.901	Q2KHU8 →
P35585	—	0.901	P35585 →
P81795	—	0.900	P81795 →
Q5ZHS1	—	0.899	Q5ZHS1 →
P43308	—	0.899	P43308 →
F1QGW6	—	0.899	F1QGW6 →
P41091	—	0.898	P41091 →
P20461	—	0.898	P20461 →
P53033	—	0.898	P53033 →
Q9Z0N1	—	0.898	Q9Z0N1 →
Q99LG2	—	0.897	Q99LG2 →