TMED2 — 15 ClinVar variants
All ClinVar germline TMED2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
15 Uncertain significance
Full TMED2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMED2 p.Ala13Thr Uncertain significance Single submitter
- TMED2 p.Arg97Trp Uncertain significance Single submitter
- TMED2 p.Glu35Lys Uncertain significance Single submitter
- TMED2 p.Glu75Gln Uncertain significance Single submitter
- TMED2 p.Gly68Glu Uncertain significance Single submitter
- TMED2 p.Leu4Val Uncertain significance Single submitter
- TMED2 p.Lys42Arg Uncertain significance Single submitter
- TMED2 p.Met107Leu Uncertain significance Single submitter
- TMED2 p.Met141Val Uncertain significance Single submitter
- TMED2 p.Thr3Ser Uncertain significance Single submitter
- TMED2 p.Val144Ile Uncertain significance Single submitter
- TMED2 p.Val2Leu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All TMED2 variants
Uncertain significance 15
- p.Ala13Thr Single submitter ⚠
- p.Arg97Trp Single submitter ⚠
- p.Asp163Asn Single submitter
- p.Glu152Ala Single submitter
- p.Glu35Lys Single submitter ⚠
- p.Glu75Gln Single submitter ⚠
- p.Gly68Glu Single submitter ⚠
- p.Leu4Val Single submitter ⚠
- p.Lys42Arg Single submitter ⚠
- p.Met107Leu Single submitter ⚠
- p.Met141Val Single submitter ⚠
- p.Thr3Ser Single submitter ⚠
- p.Thr62Ala Single submitter ⚠
- p.Val144Ile Single submitter ⚠
- p.Val2Leu Single submitter ⚠