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Sugi Predict / Targets / TMEM109

TMEM109

Voltage-gated monoatomic cation channel TMEM109 · Q9BVC6 · TMEM109 on Sugi Atlas →

0 patent compounds predicted against TMEM109, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to TMEM109 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. PHASE2NOT_YET_RECRUITING
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy PHASE1/PHASE2RECRUITING
4-Aminopyridine in Episodic Ataxia Type 2 PHASE2WITHDRAWN
A Phase I/II, First-In-Human Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Activity to Prevent or Treat Neuropsychiatric Symptoms in Pediatric Subjects With Timothy Syndrome PHASE1/PHASE2NOT_YET_RECRUITING
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK PHASE1COMPLETED
Safety and Tolerability of Intravitreal Administration of VG901 in Patients With Retinitis Pigmentosa Due to Mutations in the CNGA1 Gene PHASE1RECRUITING
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants nanRECRUITING
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Painful Channelopathies Study nanUNKNOWN
Multidisciplinary Study of Right Ventricular Dysplasia nanCOMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
The Natural History of TRPV4 Neuropathy nanRECRUITING
Role of TMEM219 Marker in Type 1 Diabetes nanUNKNOWN
Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis nanCOMPLETED
Feasibility of Improving Risk Stratification in Brugada Syndrome nanCOMPLETED
Clinical-genetic Investigations in Children With Early Infantile Epilepsies nanCOMPLETED
Energy Balance and Weight Gain With Ivacaftor Treatment nanCOMPLETED
Comparison Between Ultra-low-dose Computed Tomography and Lung MRI in Cystic Fibrosis nanCOMPLETED
The Genetic Basis of Atrial Fibrillation (AF) nanCOMPLETED
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome nanRECRUITING
Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies nanRECRUITING
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism nanCOMPLETED
Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH) nanRECRUITING
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias nanRECRUITING
Classical Trigeminal Neuralgia and Sodium Channel Mutations nanCOMPLETED
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TMEM109 binder may also engage these)

ProteinNameSimilarity
Q3UBX0 — 1.000 Q3UBX0 →
Q6AYQ4 — 0.999 Q6AYQ4 →
O77751 — 0.995 O77751 →
BRI3BP BRI3-binding protein 0.986 landscape →
Q8BT42 — 0.982 Q8BT42 →
Q8BXV2 — 0.981 Q8BXV2 →
H9FNA4 — 0.980 H9FNA4 →
E1BAR0 — 0.980 E1BAR0 →
Q69YL0 — 0.980 Q69YL0 →
Q28FG4 — 0.979 Q28FG4 →
P0DKU8 — 0.979 P0DKU8 →
A0A096P2H7 — 0.979 A0A096P2H7 →
Q6GMB1 — 0.979 Q6GMB1 →
P0DPH4 — 0.979 P0DPH4 →
Q52NJ0 — 0.979 Q52NJ0 →
P0DM83 — 0.978 P0DM83 →
P0DTG3 — 0.978 P0DTG3 →
Q9Z0S9 — 0.978 Q9Z0S9 →
P0DPH2 — 0.978 P0DPH2 →
P0DTR7 — 0.978 P0DTR7 →
P0DPH6 — 0.978 P0DPH6 →
P18657 — 0.978 P18657 →
Q3U1N2 — 0.978 Q3U1N2 →
P0DMP9 — 0.977 P0DMP9 →
P0DTT4 — 0.977 P0DTT4 →
P0DTT3 — 0.977 P0DTT3 →
P0CE38 — 0.977 P0CE38 →
P0DMA7 — 0.977 P0DMA7 →
Q298S5 — 0.977 Q298S5 →
Q0V9G6 — 0.977 Q0V9G6 →