Sugi Predict

Sugi Predict / Targets / TMEM165

TMEM165

Putative divalent cation/proton antiporter TMEM165 · Q9HC07 · TMEM165 on Sugi Atlas →

0 patent compounds predicted against TMEM165, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to TMEM165 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome PHASE2WITHDRAWN
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. PHASE2NOT_YET_RECRUITING
Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential Diagnosis Between Ferroportin Disease and Dysmetabolic Hepatosiderosis. PHASE2COMPLETED
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis EARLY_PHASE1RECRUITING
Brain P-gp and Inflammation in People With Epilepsy nanCOMPLETED
Genes-in-Action - Hepcidin Regulation of Iron Supplementation nanCOMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Mapping Novel Disease Genes for Dilated Cardiomyopathy nanCOMPLETED
Comparison Between Ultra-low-dose Computed Tomography and Lung MRI in Cystic Fibrosis nanCOMPLETED
Genetic Study of Age-Related Macular Degeneration nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Incidence of Iron Deficiency in Polycythemia Vera (PV) and Association With Disease Features nanUNKNOWN
Identifying Diuretic Resistance in Patients With Acute Heart Failure nanCOMPLETED
The Role of Arachidonic Acid Metabolites, From Patients With Metabolic Syndrome nanUNKNOWN
Transporter Mediated Uptake of Montelukast nanCOMPLETED
Stone Disease in Children and Their Families nanCOMPLETED
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital nanUNKNOWN
Celiac Disease Genomic Environmental Microbiome and Metabolomic Study nanRECRUITING
Oxalate and Citrate in Humans - Response to Citrate nanRECRUITING
Identification and Characterization of Monogenic Diabetes nanCOMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts nanCOMPLETED
Cardiac Structure and Function in Patients with Cystic Fibrosis nanACTIVE_NOT_RECRUITING
Organoid Study R334W nanWITHDRAWN
Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis nanCOMPLETED
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study nanCOMPLETED
Hemochromatosis and Iron Overload Screening Study (HEIRS) nanCOMPLETED
Gene Modifiers of Cystic Fibrosis Lung Disease nanACTIVE_NOT_RECRUITING
Bile Acid Effects in Fetal Arrhythmia Study nanUNKNOWN
Clinical and Genetic Examinations of Dilated Cardiomyopathy nanCOMPLETED
Seven Year Update of Macular Degeneration Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TMEM165 binder may also engage these)

ProteinNameSimilarity
Q4V899 — 0.999 Q4V899 →
P52875 — 0.997 P52875 →
GLS Glutaminase kidney isoform, mitochondrial 0.939 landscape →
Q4R8V4 — 0.933 Q4R8V4 →
P13264 — 0.932 P13264 →
D3Z7P3 — 0.931 D3Z7P3 →
P57791 — 0.927 P57791 →
Q8R4D1 — 0.925 Q8R4D1 →
Q91VM4 — 0.924 Q91VM4 →
KCNT1 Potassium channel subfamily T member 1 0.923 landscape →
Q4W5Z4 — 0.923 Q4W5Z4 →
SPNS2 Sphingosine-1-phosphate transporter SPNS2 0.922 landscape →
Q4L208 — 0.919 Q4L208 →
B0BMW8 — 0.919 B0BMW8 →
O43688 — 0.919 O43688 →
Q8C6G8 — 0.918 Q8C6G8 →
Q8C811 — 0.918 Q8C811 →
Q28D01 — 0.918 Q28D01 →
Q5ZJ75 — 0.918 Q5ZJ75 →
RCE1 CAAX prenyl protease 2 0.918 landscape →
P0CK96 — 0.918 P0CK96 →
Q6PCB6 — 0.918 Q6PCB6 →
Q2HJ19 — 0.917 Q2HJ19 →
WDR26 WD repeat-containing protein 26 0.916 landscape →
Q8VCV1 — 0.916 Q8VCV1 →
P60588 — 0.915 P60588 →
O14494 — 0.915 O14494 →
B5DFK7 — 0.915 B5DFK7 →
Q13888 — 0.915 Q13888 →
Q6P1K8 — 0.915 Q6P1K8 →