TMEM63A

Mechanosensitive cation channel TMEM63A · O94886 · TMEM63A on Sugi Atlas →

0 patent compounds predicted against TMEM63A, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to TMEM63A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy PHASE2RECRUITING
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators. PHASE2NOT_YET_RECRUITING
StereoTactic Arrhythmia Radiotherapy in the NetherLands no. 2 PHASE2RECRUITING
Vibration Therapy Effects on Muscle Firing Patterns PHASE1/PHASE2COMPLETED
Biomechanical Analysis of Distal Radius (Greenstick) Fracture Healing PHASE1/PHASE2NOT_YET_RECRUITING
Safety and Tolerability of Inhaled Nitric Oxide in Patients With Cystic Fibrosis PHASE1/PHASE2COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene nanRECRUITING
Piezo2-related Arthrogryposis & physiopathOLOgy 3 nanNOT_YET_RECRUITING
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants nanRECRUITING
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
A P2X7R Single Nucleotide Mutation Promotes Chronic Allograft Vasculopathy nanCOMPLETED
Painful Channelopathies Study nanUNKNOWN
Multidisciplinary Study of Right Ventricular Dysplasia nanCOMPLETED
The Natural History of TRPV4 Neuropathy nanRECRUITING
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Pulsed Radiofrequency in Chronic Lumbosacral Radicular Pain nanCOMPLETED
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis nanCOMPLETED
Affective Touch, Hedonia and Suicidal Behavior nanCOMPLETED
Heart and Skeletal Muscle Problems in Neuroacanthocytosis nanCOMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
A Study on the Mechanism of Cough Hypersensitivity nanUNKNOWN
Implication of UNconventionaL T Lymphocytes in Cystic Fibrosis (UNLOCk) nanCOMPLETED
Exploring the Genetics of Neuropathic Pain nanRECRUITING
Identifying Diuretic Resistance in Patients With Acute Heart Failure nanCOMPLETED
Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis nanCOMPLETED
Performance Determinants Factors in Elite Endurance Athletes. nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TMEM63A binder may also engage these)

ProteinNameSimilarity
Q5R826 1.000 Q5R826 →
A0A452G813 1.000 A0A452G813 →
Q91YT8 1.000 Q91YT8 →
Q9P1W3 1.000 Q9P1W3 →
D3ZNF5 1.000 D3ZNF5 →
Q8CBX0 0.996 Q8CBX0 →
A0A8V0ZB02 0.995 A0A8V0ZB02 →
X1WEM4 0.995 X1WEM4 →
Q5T3F8 0.994 Q5T3F8 →
Q3TWI9 0.991 Q3TWI9 →
Q6NP91 0.990 Q6NP91 →
ABCC8 ATP-binding cassette sub-family C member 8 0.986 landscape →
F4I248 0.985 F4I248 →
F4JCY2 0.985 F4JCY2 →
Q09429 0.985 Q09429 →
Q8C428 0.984 Q8C428 →
Q6IFT6 0.983 Q6IFT6 →
Q7Q5R7 0.983 Q7Q5R7 →
Q09427 0.983 Q09427 →
Q7Z402 0.982 Q7Z402 →
A9LIW2 0.982 A9LIW2 →
Q14AT5 0.982 Q14AT5 →
Q9HBG4 0.982 Q9HBG4 →
Q9SZT4 0.981 Q9SZT4 →
Q9JIS8 0.981 Q9JIS8 →
Q4R7U0 0.981 Q4R7U0 →
Q8GUH7 0.981 Q8GUH7 →
Q7Z3F1 0.981 Q7Z3F1 →
B6HTR9 0.980 B6HTR9 →
Q5R9A7 0.980 Q5R9A7 →