TPRKB

EKC/KEOPS complex subunit TPRKB · Q9Y3C4 · TPRKB on Sugi Atlas →

0 patent compounds predicted against TPRKB, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to TPRKB by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers PHASE1/PHASE2NOT_YET_RECRUITING
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety PHASE2COMPLETED
TNFSF11 Inhibition and Fertility: a Prospective Study PHASE2COMPLETED
Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients PHASE1/PHASE2COMPLETED
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy PHASE2RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors PHASE1COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders nanCOMPLETED
Genotype-phenotype Correlation in Junctional Epidermolysis Bullosa nanUNKNOWN
Mechanisms of Resistance to Amivantamab in Patients With NSCLC With EGFR Exon 20 Insertion nanRECRUITING
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Exploiting Epigenome Editing in Kabuki Syndrome: a New Route Towards Gene Therapy for Rare Genetic Disorders nanCOMPLETED
Urinary Kallikrein and Hypertension: A Prospective Study nanCOMPLETED
Genetic Analysis of Familial Hypertrophic Cardiomyopathy nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients nanCOMPLETED
Mapping Novel Disease Genes for Dilated Cardiomyopathy nanCOMPLETED
Steroid Treatment of Idiopathic Nephrotic Syndrome nanCOMPLETED
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH) nanRECRUITING
Risk Burden of Lipoprotein Metabolic Gene Haplotypes nanCOMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI nanRECRUITING
Study of Proteins in Head and Neck Cancer Cells nanCOMPLETED
Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods nanUNKNOWN
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease nanCOMPLETED
Relationship Between Genes Important in Blood Pressure Regulation and Blood Pressure Therapy in Hypertension nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TPRKB binder may also engage these)

ProteinNameSimilarity
Q8QZZ7 0.997 Q8QZZ7 →
Q6LX55 0.988 Q6LX55 →
Q97PH3 0.988 Q97PH3 →
B2IRP8 0.987 B2IRP8 →
B5E6S0 0.987 B5E6S0 →
P32285 0.987 P32285 →
O33575 0.986 O33575 →
B1I710 0.986 B1I710 →
Q04JC5 0.986 Q04JC5 →
Q0K929 0.986 Q0K929 →
C1C8N4 0.985 C1C8N4 →
M1L511 0.985 M1L511 →
Q48244 0.985 Q48244 →
P86833 0.984 P86833 →
P20981 0.984 P20981 →
Q202I6 0.984 Q202I6 →
O33509 0.984 O33509 →
C1CLY4 0.984 C1CLY4 →
O67549 0.984 O67549 →
Q1WTX9 0.984 Q1WTX9 →
O33510 0.984 O33510 →
P03295 0.983 P03295 →
O76616 0.983 O76616 →
B2TN01 0.983 B2TN01 →
Q4QLV1 0.983 Q4QLV1 →
P44954 0.983 P44954 →
P27711 0.983 P27711 →
P86237 0.983 P86237 →
Q914K3 0.983 Q914K3 →
F1QZ15 0.983 F1QZ15 →