TRAF6 — 37 ClinVar variants
All ClinVar germline TRAF6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Benign · 6 Likely benign · 30 Uncertain significance
Full TRAF6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRAF6 p.Ala194Thr Uncertain significance Single submitter
- TRAF6 p.Arg167His Uncertain significance Single submitter
- TRAF6 p.Asn212Ser Uncertain significance Single submitter
- TRAF6 p.Asp181Ala Uncertain significance Single submitter
- TRAF6 p.Glu225Gln Uncertain significance Single submitter
- TRAF6 p.Gly358Ser Uncertain significance Single submitter
- TRAF6 p.His421Gln Uncertain significance Single submitter
- TRAF6 p.Ile174Val Uncertain significance Single submitter
- TRAF6 p.Ile203Met Uncertain significance Single submitter
- TRAF6 p.Ile203Thr Uncertain significance Single submitter
- TRAF6 p.Ile344Val Uncertain significance Single submitter
- TRAF6 p.Leu159Phe Uncertain significance Single submitter
- TRAF6 p.Leu479Pro Uncertain significance Single submitter
- TRAF6 p.Met253Val Uncertain significance Single submitter
- TRAF6 p.Met270Arg Uncertain significance Single submitter
- TRAF6 p.Met325Ile Uncertain significance Single submitter
- TRAF6 p.Met362Ile Uncertain significance Single submitter
- TRAF6 p.Met362Val Uncertain significance Single submitter
- TRAF6 p.Ser195Pro Uncertain significance Single submitter
- TRAF6 p.Ser286Pro Uncertain significance Single submitter
- TRAF6 p.Val282Ile Uncertain significance Single submitter
- TRAF6 p.Val307Ile Uncertain significance Single submitter
- TRAF6 p.Val522Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TRAF6 variants
Benign 1
- c.448-15dup No assertion criteria
Likely benign 6
- p.Asp161Asn Single submitter
- p.Ile176= Single submitter
- p.Ile283Thr Single submitter
- p.Met196Val Single submitter
- p.Pro183= Single submitter
- p.Met160Thr No assertion criteria TRAF6-related disorder
Uncertain significance 30
- p.Ala194Thr Single submitter ⚠
- p.Arg167His Single submitter ⚠
- p.Arg402His Single submitter
- p.Asn212Ser Single submitter ⚠
- p.Asp181Ala Single submitter ⚠
- p.Glu114Asp Single submitter ⚠
- p.Glu144Lys Single submitter ⚠
- p.Glu225Gln Single submitter ⚠
- p.Glu345Lys Single submitter ⚠
- p.Gly358Ser Single submitter ⚠
- p.Gly521Arg Single submitter
- p.His421Gln Single submitter ⚠
- p.Ile174Val Single submitter ⚠
- p.Ile203Met Single submitter ⚠
- p.Ile203Thr Single submitter ⚠
- p.Ile344Val Single submitter ⚠
- p.Leu159Phe Single submitter ⚠
- p.Leu479Pro Single submitter ⚠
- p.Met253Ile Single submitter ⚠
- p.Met253Val Single submitter ⚠
- p.Met270Arg Single submitter ⚠
- p.Met325Ile Single submitter ⚠
- p.Met362Ile Single submitter ⚠
- p.Met362Val Single submitter ⚠
- p.Ser195Pro Single submitter ⚠
- p.Ser286Pro Single submitter ⚠
- p.Ser420Arg Single submitter ⚠
- p.Val282Ile Single submitter ⚠
- p.Val307Ile Single submitter ⚠
- p.Val522Leu Single submitter ⚠