TRIM59 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to TRIM59 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can We Achieve 'high-quality' Weight Loss Through Supplementation and Exercise? the TRIM MUSCLE Study	PHASE3	COMPLETED
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
Phase I Safety and Immunogenicity Preventative Vaccine Trial Based on Recombinant Tat Protein	PHASE1	COMPLETED
Signaling Pathways Targeting Colorectal Cancer in Egypt	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Biomarkers of Cancer-Associated Myositis	nan	ACTIVE_NOT_RECRUITING
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse	nan	ACTIVE_NOT_RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Family Blood Pressure Program - SAPPHIRe Network	nan	COMPLETED
Family Blood Pressure Program - GENOA	nan	COMPLETED
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis	nan	UNKNOWN
Family Blood Pressure Program - HyperGEN	nan	COMPLETED
The Effect of Exercise Training on Skeletal Muscle Metabolism in Peripheral Artery Disease (PAD)	nan	UNKNOWN
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Prospective Evaluation of Biomarkers Variability in Knee Prosthetic Surgery	nan	COMPLETED
The Efficiency of Postoperative Interferon-alpha Treatment in p48 Positive Patients With Hepatocellular Carcinoma	nan	WITHDRAWN
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
NLRP3 Inflammasome and Physical Therapy in ICU-Acquired Weakness	nan	RECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Role of MicroRNAs on Age and Contraction-induced Skeletal Muscle Growth	nan	COMPLETED
Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TRIM59 binder may also engage these)

Protein	Name	Similarity
Q922Y2	—	1.000	Q922Y2 →
Q9CYB0	—	0.999	Q9CYB0 →
Q5ZMD4	—	0.996	Q5ZMD4 →
F6ZQ54	—	0.994	F6ZQ54 →
O60858	—	0.992	O60858 →
Q5M7V1	—	0.991	Q5M7V1 →
Q32L60	—	0.985	Q32L60 →
A0A386CAB9	—	0.984	A0A386CAB9 →
Q8TDB6	—	0.984	Q8TDB6 →
Q503I2	—	0.984	Q503I2 →
Q9BZR9	—	0.984	Q9BZR9 →
Q8BMD7	—	0.983	Q8BMD7 →
Q5BIW4	—	0.983	Q5BIW4 →
Q9D2H5	—	0.983	Q9D2H5 →
Q9ESK9	—	0.982	Q9ESK9 →
Q7TPV2	—	0.982	Q7TPV2 →
Q6IVY4	—	0.982	Q6IVY4 →
Q09654	—	0.982	Q09654 →
Q80VH0	—	0.981	Q80VH0 →
PIK3C2A	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0.981	landscape →
O88196	—	0.981	O88196 →
A6QR20	—	0.980	A6QR20 →
Q90WN7	—	0.980	Q90WN7 →
P36407	—	0.980	P36407 →
Q95LP3	—	0.979	Q95LP3 →
GTF3C4	General transcription factor 3C polypeptide 4	0.979	landscape →
Q28132	—	0.979	Q28132 →
Q4VSN5	—	0.979	Q4VSN5 →
Q9C0F1	—	0.979	Q9C0F1 →
Q2MH06	—	0.979	Q2MH06 →