TUFM

Elongation factor Tu, mitochondrial · P49411 · TUFM on Sugi Atlas →

1,715 patent compounds predicted against TUFM, 1,460 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Gilteritinib (SCHEMBL282229)	1.00	1/20
SCHEMBL328303	0.94	1/20
Gilteritinib (SCHEMBL21819929)	0.92	1/20
Gilteritinib (SCHEMBL22684910)	0.91	1/20
Gilteritinib (SCHEMBL22684912)	0.91	1/20
SCHEMBL21455071	0.89	1/20
SCHEMBL22652336	0.89	1/20
SCHEMBL10156928	0.89	1/20
Gilteritinib (SCHEMBL22684909)	0.88	1/20
Gilteritinib (SCHEMBL22684903)	0.87	1/20
SCHEMBL22694087	0.87	1/20
SCHEMBL21426963	0.86	1/20
SCHEMBL21427160	0.86	1/20
Gilteritinib (SCHEMBL23149445)	0.86	1/20
SCHEMBL25483843	0.86	1/20
SCHEMBL25483845	0.86	1/20
SCHEMBL282490	0.85	1/20
SCHEMBL282491	0.85	1/20
Gilteritinib (SCHEMBL22684907)	0.85	1/20
SCHEMBL22694094	0.85	1/20

Clinical trials — most relevant to TUFM by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Biologic Correlative Taxotere/AC	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Effect of Diaphragm Stimulation During Surgery	nan	COMPLETED
Mitochondrial Assessment in Critical Ill Patients in Intensive Care	nan	NOT_YET_RECRUITING
Mitoquines in COPD	nan	UNKNOWN
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure?	nan	RECRUITING
Mitochondrial Dysfunction in Diabetes	nan	COMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis	nan	COMPLETED
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis	nan	COMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a TUFM binder may also engage these)

Protein	Name	Similarity
P49410	—	1.000	P49410 →
P85834	—	1.000	P85834 →
Q8BFR5	—	1.000	Q8BFR5 →
Q9Y700	—	0.999	Q9Y700 →
Q54HB2	—	0.999	Q54HB2 →
Q32PH8	—	0.998	Q32PH8 →
Q9ZT91	—	0.998	Q9ZT91 →
P62631	—	0.998	P62631 →
P02992	—	0.996	P02992 →
Q3ZXX3	—	0.996	Q3ZXX3 →
B0W010	—	0.995	B0W010 →
EEF1A2	Elongation factor 1-alpha 2	0.995	landscape →
P02991	—	0.995	P02991 →
P17746	—	0.995	P17746 →
A5FQQ5	—	0.994	A5FQQ5 →
Q40450	—	0.994	Q40450 →
Q43364	—	0.994	Q43364 →
Q5R8Z3	—	0.994	Q5R8Z3 →
P05197	—	0.994	P05197 →
P55823	—	0.993	P55823 →
A9ETD1	—	0.993	A9ETD1 →
P58252	—	0.993	P58252 →
P50372	—	0.993	P50372 →
Q2K9L8	—	0.993	Q2K9L8 →
P25039	—	0.993	P25039 →
A7A0X4	—	0.993	A7A0X4 →
Q3Z7S9	—	0.993	Q3Z7S9 →
A4FWF0	—	0.993	A4FWF0 →
B5VN01	—	0.993	B5VN01 →
Q754I9	—	0.993	Q754I9 →