VAT1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16637284	1.00	1/20
SCHEMBL18128690	0.93	1/20
SCHEMBL16647182	0.88	1/20
SCHEMBL16646915	0.84	1/20
SCHEMBL18842314	0.83	1/20
SCHEMBL18128425	0.82	1/20
SCHEMBL18963672	0.81	1/20
SCHEMBL18964390	0.81	1/20
SCHEMBL17030812	0.80	1/20
SCHEMBL16647110	0.80	1/20
SCHEMBL18128369	0.80	1/20
SCHEMBL16646906	0.80	1/20
SCHEMBL18128738	0.79	1/20
SCHEMBL16646901	0.79	1/20
SCHEMBL16636979	0.78	1/20
SCHEMBL16647071	0.78	1/20
SCHEMBL16646882	0.77	1/20
SCHEMBL18128620	0.77	1/20
SCHEMBL16637403	0.77	1/20
SCHEMBL19084490	0.76	1/20

Clinical trials — most relevant to VAT1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma	PHASE3	COMPLETED
Effect of Montelukast Versus Co Enzyme in Sepsis	PHASE2/PHASE3	COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Effect of Diaphragm Stimulation During Surgery	nan	COMPLETED
Influence of Diabetic Neuropathy on Activation of Brown Adipose Tissue	nan	UNKNOWN
Testing Drug Efficacy in Cystic Fibrosis Through N-of-1 Trials	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
The Safety and Efficacy Study of RiaGev in Healthy Adults	nan	UNKNOWN
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
Role of Vitamin C Infusion in Postoperative Mechanically Ventilated Neonates With Sepsis	nan	COMPLETED
Covid-19: Possible Role of Neutrophil Extracellular Traps	nan	UNKNOWN
Lung Mucus Hypersecretion and NQO1	nan	COMPLETED
Diagnostic Odyssey Survey 2	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Evaluate the Effort Test as a Therapeutic Monitoring Tool in Acute Rhabdomyolyses	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Study of Protein Translocation in Patients With Beta-Oxidation Disorders	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a VAT1 binder may also engage these)

Protein	Name	Similarity
Q3MIE4	—	0.998	Q3MIE4 →
Q62465	—	0.995	Q62465 →
Q9HCJ6	—	0.974	Q9HCJ6 →
Q80TB8	—	0.971	Q80TB8 →
Q8JFV8	—	0.950	Q8JFV8 →
Q24K16	—	0.948	Q24K16 →
Q8BGC4	—	0.947	Q8BGC4 →
Q28452	—	0.945	Q28452 →
Q8N4Q0	—	0.944	Q8N4Q0 →
P47199	—	0.943	P47199 →
Q3T0R4	—	0.942	Q3T0R4 →
Q6AYT0	—	0.941	Q6AYT0 →
Q3UNZ8	—	0.941	Q3UNZ8 →
A6QP05	—	0.938	A6QP05 →
P13603	—	0.938	P13603 →
Q0ITW7	—	0.937	Q0ITW7 →
P48977	—	0.937	P48977 →
B0BNC9	—	0.937	B0BNC9 →
Q4R1E8	—	0.937	Q4R1E8 →
Q5R6U1	—	0.937	Q5R6U1 →
Q9BV79	—	0.936	Q9BV79 →
Q99J47	—	0.936	Q99J47 →
Q96NN9	—	0.936	Q96NN9 →
P25141	—	0.936	P25141 →
P12886	—	0.935	P12886 →
P10848	—	0.935	P10848 →
Q28GQ2	—	0.935	Q28GQ2 →
Q9UI17	—	0.934	Q9UI17 →
Q0MVN8	—	0.934	Q0MVN8 →
Q5R514	—	0.934	Q5R514 →