VSIR

V-type immunoglobulin domain-containing suppressor of T-cell activation · Q9H7M9 · VSIR on Sugi Atlas →

7,290 patent compounds predicted against VSIR, 2,264 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL205664 SCHEMBL205664 0.62 14/20
SCHEMBL206075 SCHEMBL206075 0.63 12/20
SCHEMBL2945766 SCHEMBL2945766 0.62 10/20
SCHEMBL2942666 SCHEMBL2942666 0.67 9/20
SCHEMBL2943147 SCHEMBL2943147 0.48 9/20
SCHEMBL4474314 SCHEMBL4474314 0.60 8/20
SCHEMBL6381122 SCHEMBL6381122 0.57 8/20
SCHEMBL2950004 SCHEMBL2950004 0.56 8/20
SCHEMBL2949787 SCHEMBL2949787 0.56 8/20
SCHEMBL2941655 SCHEMBL2941655 0.50 8/20
SCHEMBL2949229 SCHEMBL2949229 0.46 8/20
SCHEMBL2950570 SCHEMBL2950570 0.45 8/20
SCHEMBL2942671 SCHEMBL2942671 0.53 7/20
SCHEMBL2949312 SCHEMBL2949312 0.53 7/20
SCHEMBL2941593 SCHEMBL2941593 0.51 7/20
SCHEMBL2948346 SCHEMBL2948346 0.48 7/20
SCHEMBL2949248 SCHEMBL2949248 0.48 7/20
SCHEMBL2947490 SCHEMBL2947490 0.48 7/20
SCHEMBL2947492 SCHEMBL2947492 0.48 7/20
SCHEMBL2940607 SCHEMBL2940607 0.47 7/20

Clinical trials — most relevant to VSIR by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease PHASE4UNKNOWN
Understanding the Immune Response to Two Different Meningitis Vaccines PHASE4COMPLETED
A Study to Evaluate IGSC 20% Biweekly Dosing in Treatment-Experienced Participants and Loading/Maintenance Dosing in Treatment-Naïve Participants With Primary Immunodeficiency PHASE4COMPLETED
V-IMMUNE: A Novel Immunoglobulin Therapy for Immunodeficiency PHASE3RECRUITING
A Clinical Study of Intravenous Immunoglobulin PHASE3COMPLETED
ZyVac-TCV Bangladesh Study PHASE3NOT_YET_RECRUITING
Safety and Pharmacokinetics of IGSC 20% in Subjects With Primary Immunodeficiency PHASE3COMPLETED
Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) PHASE3COMPLETED
Pembrolizumab (MK-3475) in MM Patients With Residual Disease PHASE2COMPLETED
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma PHASE2RECRUITING
Pembrolizumab and Induction Chemotherapy in Head and Neck Squamous Cell Carcinoma (PICH Study) PHASE1/PHASE2WITHDRAWN
Pembrolizumab And Tamoxifen Among Women With Advanced Hormone Receptor Positive Breast Cancer And Esr1 Mutation PHASE2UNKNOWN
Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients. PHASE2COMPLETED
Study of Safety, Tolerability, and Efficacy of Ustekinumab for Symptomatic Gastrointestinal Inflammation Associated With Common Variable Immunodeficiency PHASE1/PHASE2COMPLETED
Llama Antibody, Rotavirus Diarrhoea, Children PHASE2COMPLETED
Dose Escalation Trial of CD40.HIVRI.Env Vaccine Combined or Not With a DNA-HIV-PT123 HIV-1 Vaccine in Healthy Volunteers PHASE1COMPLETED
Analysis of the Mechanisms of Protective Humoral Immunity in Response to the Pneumococcal Vaccine PHASE1COMPLETED
A Phase I Study of ABT-510 in Combination With Bevacizumab in Advanced Solid Tumors PHASE1COMPLETED
68Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid Arthritis EARLY_PHASE1UNKNOWN
Modulatory Effect of Prodigiosin or Pioglitazone on TIME and the Crosstalk to Immune-Checkpoint Protein(s) nanNOT_YET_RECRUITING
VDJ-recombination of the B-cell Receptor Following Hematopoietic Stem Cell Transplantation nanNOT_YET_RECRUITING
GLILD Diagnosed in Children and Young Adults With Common Variable Immunodeficiency nanUNKNOWN
Impaired Secretory IgA and Mucosal Immunity in Cystic Fibrosis nanUNKNOWN
Impact of Seasonal Malaria Chemoprevention on Immunity Against Malaria Among Children in Northern Benin nanCOMPLETED
Angiogenesis and Fibrosis in Aortic Stenosis nanCOMPLETED
High Definition Profiling of Ovarian Cancer Ascites nanNOT_YET_RECRUITING
Clinical Application of PET Imaging Targeting GPA33 in Malignant Tumors nanNOT_YET_RECRUITING
Role of Neutrophil Activation in Anaphylaxis to Neuro-Muscular Blocking Agents nanCOMPLETED
Non-invasive Tumor Immunoglobulin Gene Next Generation Sequencing (IgNGS) in Diffuse Large B Cell Lymphoma (DLBCL) nanUNKNOWN
Immune Checkpoints in Predicting Response to Neoadjuvant Therapy in Rectal Cancer nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a VSIR binder may also engage these)

ProteinNameSimilarity
Q9D659 1.000 Q9D659 →
Q8R4V1 0.998 Q8R4V1 →
P26896 0.994 P26896 →
P16297 0.994 P16297 →
Q8N386 0.993 Q8N386 →
Q38J84 0.993 Q38J84 →
Q8BLR5 0.992 Q8BLR5 →
Q6AXU5 0.992 Q6AXU5 →
Q8K1T1 0.991 Q8K1T1 →
Q8NET5 0.991 Q8NET5 →
Q96PD2 0.990 Q96PD2 →
Q8CFD9 0.989 Q8CFD9 →
Q01151 0.989 Q01151 →
Q8BHW9 0.989 Q8BHW9 →
A1KXC4 0.989 A1KXC4 →
P98162 0.989 P98162 →
O14931 0.989 O14931 →
Q8BWG4 0.988 Q8BWG4 →
T1NXB5 0.988 T1NXB5 →
Q8MJ02 0.988 Q8MJ02 →
Q64322 0.988 Q64322 →
Q9Y426 0.988 Q9Y426 →
Q80UW3 0.988 Q80UW3 →
A6QQC6 0.988 A6QQC6 →
Q86UW2 0.988 Q86UW2 →
P61483 0.988 P61483 →
Q9D8D0 0.987 Q9D8D0 →
P61484 0.987 P61484 →
A8MVW5 0.987 A8MVW5 →
Q7TSF4 0.987 Q7TSF4 →