Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 15/20 | 0.66 |
| ▸ | WNT1 | P04628 | 12/20 | 0.66 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523358 | 0.93 | DYRK1A (0.58) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL4514663 | 0.88 | DYRK1A (0.52) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL6219544 | 0.85 | DYRK1A (0.72) | DYRK1AWNT1GSK3BACHEKCNH2 | |
| SCHEMBL20125806 | 0.82 | DYRK1A (0.71) | DYRK1AWNT1GSK3BACHEKCNH2 | |
| SCHEMBL954666 | 0.81 | KDM4E (0.64) | — | |
| SCHEMBL6221024 | 0.81 | DYRK1A (0.56) | DYRK1AWNT1GSK3BACHEKCNH2 | |
| SCHEMBL82655 | 0.81 | DYRK1A (0.70) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL17096021 | 0.79 | DYRK1A (1.00) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL953365 | 0.78 | DYRK1A (0.61) | DYRK1AWNT1GSK3BROCK2CLK2 | |
| SCHEMBL4513095 | 0.78 | DYRK1A (0.62) | DYRK1AWNT1GSK3BACHEKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4762543-B2 | — | — | 2011-08-31 | — | — | JP | claimed |
| EP-1549620-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | Sanofi-Aventis (FR) | 2005-07-06 | — | — | EP | claimed |
| WO-2004031158-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | SANOFI-AVENTIS (FR) | 2004-04-15 | — | — | WO | claimed |
| EP-1549620-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | Sanofi-Aventis (FR) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031158-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | SANOFI-AVENTIS (FR) | 2004-04-15 | — | — | WO | disclosed |