Is ADGRE3 p.Val263Met (c.787G>A) pathogenic?

ADGRE3 p.Val263Met (c.787G>A) is classified Uncertain significance in ADGRE3 (ClinVar, Single submitter, 1 submitter; last evaluated 2021-09-16). AlphaMissense: likely benign (0.1554); Rare (popmax 0.163%, afr).

How common is ADGRE3 p.Val263Met (c.787G>A) in the general population?

ADGRE3 p.Val263Met (c.787G>A) is rare (popmax 0.163%, afr) (gnomAD).

What do computational predictors say about ADGRE3 p.Val263Met (c.787G>A)?

AlphaMissense predicts likely benign (score 0.1554) — an in-silico prediction, not a clinical call.

ADGRE3 p.Val263Met

c.787G>A · rs150299594 · VCV2355431

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.1554 · ACMG-weighted

gnomAD v4.1

Rare

rare (popmax 0.163%, afr)

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.1554	likely benign
REVEL	0.013	strongly benign-leaning
SaProt	LLR -9.46	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	<0.2	all four deltas below 0.2 · C>A here scores Δ0.34 · evaluated, not missing
Constraint at this position
Conservation	phyloP -4	GERP -8.1
Regional constraint	o/e 0.92	unconstrained · MANE · 55 kb · p 0.027 · regional, not allelic
Overall
CADD	0.141	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.163% African / African-American · 122/74,888 alleles

Filtering AF 0.139% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.131%

Overall 0.00905% 146/1,613,198 alleles · rare

Ancestry group	Frequency	1 in
African / African-Americangrpmax	0.163%	614
Remaining individualsnot grpmax-eligible	0.00801%	12,490
Admixed American	0.00667%	14,997
European (non-Finnish)	0.00127%	78,619

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: ADGRE3
Protein: p.Val263Met
Coding: c.787G>A
MANE Select: NM_032571
dbSNP: rs150299594
Type: single nucleotide variant
Location: chr19:14647276 (GRCh38)
Gene constraint: LOEUF 1.265 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 80.74
Residue 263: the gain-b domain

Full ADGRE3 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

ADGRE3 p.Ala198Glu Uncertain significance ★ ⚠ same type
ADGRE3 p.Ala198Ser Uncertain significance ★ ⚠ same type
ADGRE3 p.Ala342Thr Uncertain significance ★ ⚠ same type
ADGRE3 p.Ala374Val Uncertain significance ★ ⚠ same type
ADGRE3 p.Asn39Ser Uncertain significance ★ ⚠ same type
ADGRE3 p.Asn450Asp Uncertain significance ★ ⚠ same type
ADGRE3 p.Asn538Ser Uncertain significance ★ ⚠ same type
ADGRE3 p.Asn66Asp Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/adgre3-p-val263met (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown