ADGRE3 — 94 ClinVar variants

All ClinVar germline ADGRE3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →

11 Likely benign · 83 Uncertain significance

Full ADGRE3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 83

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 44

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 39

The independent predictors disagree with each other — read with care.

All ADGRE3 variants

Likely benign 11

p.Ala198Val Single submitter
p.Ala518Val Single submitter
p.Arg154Lys Single submitter
p.Arg222His Single submitter
p.Asn211Ser Single submitter
p.Met257Thr Single submitter
p.Ser224Asn Single submitter
p.Thr209Ile Single submitter
p.Thr296Asn Single submitter
p.Val184Ile Single submitter
p.Val326Met Single submitter

Uncertain significance 83

p.Ala198Glu Single submitter ⚠
p.Ala198Ser Single submitter ⚠
p.Ala342Thr Single submitter ⚠
p.Ala374Val Single submitter ⚠
p.Asn39Ser Single submitter ⚠
p.Asn450Asp Single submitter ⚠
p.Asn538Ser Single submitter ⚠
p.Asn66Asp Single submitter ⚠
p.Asn69Lys Single submitter ⚠
p.Asn87Lys Single submitter ⚠
p.Asp190Glu Single submitter ⚠
p.Asp258Ala Single submitter ⚠
p.Asp353Tyr Single submitter ⚠
p.Asp411Tyr Single submitter ⚠
p.Cys203Arg Single submitter ⚠
p.Cys335Tyr Single submitter ⚠
p.Cys37Trp Single submitter ⚠
p.Cys398Arg Single submitter ⚠
p.Gln268His Single submitter ⚠
p.Gln312Lys Single submitter ⚠
p.Gln577His Single submitter ⚠
p.Gln603His Single submitter ⚠
p.Glu352Asp Single submitter ⚠
p.Glu414Gly Single submitter ⚠
p.Glu540Lys Single submitter ⚠
p.Glu615Lys Single submitter ⚠
p.Glu640Gly Single submitter ⚠
p.Glu89Gln Single submitter ⚠
p.Gly229Arg Single submitter ⚠
p.Gly275Ala Single submitter ⚠
p.Gly320Ala Single submitter ⚠
p.Gly562Asp Single submitter ⚠
p.Gly568Asp Single submitter ⚠
p.Gly591Ala Single submitter ⚠
p.His392Pro Single submitter ⚠
p.His488Gln Single submitter ⚠
p.Ile237Thr Single submitter ⚠
p.Ile421Asn Single submitter ⚠
p.Ile515Thr Single submitter ⚠
p.Leu282Val Single submitter ⚠
p.Leu376Pro Single submitter ⚠
p.Leu380Pro Single submitter ⚠
p.Leu550Val Single submitter ⚠
p.Lys134Asn Single submitter ⚠
p.Lys138Arg Single submitter ⚠
p.Lys178Asn Single submitter ⚠
p.Lys464Met Single submitter ⚠
p.Lys56Glu Single submitter ⚠
p.Lys611Glu Single submitter ⚠
p.Lys631Met Single submitter ⚠
p.Met257Val Single submitter ⚠
p.Met332Thr Single submitter ⚠
p.Met345Leu Single submitter ⚠
p.Met549Leu Single submitter ⚠
p.Met549Val Single submitter ⚠
p.Phe378Val Single submitter ⚠
p.Phe60Leu Single submitter ⚠
p.Pro415His Single submitter ⚠
p.Pro8Ser Single submitter ⚠
p.Ser281Cys Single submitter ⚠
p.Ser281Phe Single submitter ⚠
p.Ser281Tyr Single submitter ⚠
p.Ser396Leu Single submitter ⚠
p.Ser536Cys Single submitter ⚠
p.Ser539Asn Single submitter ⚠
p.Ser588Arg Single submitter ⚠
p.Thr116Ile Single submitter ⚠
p.Thr116Ser Single submitter ⚠
p.Thr287Met Single submitter ⚠
p.Thr310Ile Single submitter ⚠
p.Thr435Ser Single submitter ⚠
p.Trp149Arg Single submitter ⚠
p.Trp486Cys Single submitter ⚠
p.Trp612Cys Single submitter ⚠
p.Tyr242His Single submitter ⚠
p.Tyr306Ser Single submitter ⚠
p.Val172Ile Single submitter ⚠
p.Val263Met Single submitter ⚠
p.Val293Met Single submitter ⚠
p.Val343Leu Single submitter ⚠
p.Val362Ala Single submitter ⚠
p.Val366Ile Single submitter ⚠
p.Val477Ala Single submitter ⚠