Is ARSI p.Val355Met (c.1063G>A) pathogenic?

ARSI p.Val355Met (c.1063G>A) is classified Uncertain significance in ARSI (ClinVar, Single submitter, 1 submitter; last evaluated 2022-05-15). AlphaMissense: likely benign (0.2926); Ultra-rare (popmax 0.0418%, sas); Associated with Spastic paraplegia.

What condition is associated with ARSI p.Val355Met (c.1063G>A)?

ARSI p.Val355Met (c.1063G>A) is associated with Spastic paraplegia (ClinVar).

How common is ARSI p.Val355Met (c.1063G>A) in the general population?

ARSI p.Val355Met (c.1063G>A) is ultra-rare (popmax 0.0418%, sas) (gnomAD).

What do computational predictors say about ARSI p.Val355Met (c.1063G>A)?

AlphaMissense predicts likely benign (score 0.2926) — an in-silico prediction, not a clinical call.

ARSI p.Val355Met

c.1063G>A · rs375263762 · VCV1975547

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.2926 · ACMG-weighted

gnomAD v4.1

Rare

ultra-rare (popmax 0.0418%, sas)

Missense predictors

1/3 damaging

AlphaMissense, REVEL, SaProt

Conditions

Spastic paraplegia

Computational evidence

Protein change
AlphaMissense	0.2926	likely benign
REVEL	0.655	pathogenic-leaning
SaProt	LLR -9.74	tolerated
⇒ REVEL calls this damaging; AlphaMissense and SaProt do not.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 4.1	GERP -0.77, phastCons 1
Regional constraint	o/e 0.92	unconstrained · MANE · 5,156 bp · p 0.021 · regional, not allelic
Overall
CADD	23.6	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.0418% South Asian · 38/90,912 alleles

Filtering AF 0.0313% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.0276%

Overall 0.00689% 111/1,611,808 alleles · ultra-rare

Ancestry group	Frequency	1 in
South Asiangrpmax	0.0418%	2,392
European (non-Finnish)	0.00585%	17,090
Remaining individualsnot grpmax-eligible	0.0048%	20,813
African / African-American	0.00133%	75,038

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: ARSI
Protein: p.Val355Met
Coding: c.1063G>A
MANE Select: NM_001012301
dbSNP: rs375263762
Type: single nucleotide variant
Location: chr5:150297861 (GRCh38)
Gene constraint: LOEUF 1.403 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 87.35

Full ARSI gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

Spastic paraplegia — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Similar variants

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ARSI p.Ala399Asp Uncertain significance ★★ ⚠ same condition
ARSI p.Ala414Ser Uncertain significance ★★ ⚠ same condition
ARSI p.Ala414Thr Uncertain significance ★★ ⚠ same condition
ARSI p.Ala78Thr Uncertain significance ★★ ⚠ same condition
ARSI p.Arg117Cys Uncertain significance ★★ ⚠ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/arsi-p-val355met (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown