Is BRIP1 p.Arg419Trp (c.1255C>T) pathogenic?

BRIP1 p.Arg419Trp (c.1255C>T) is classified Conflicting classifications of pathogenicity in BRIP1 (ClinVar, Conflicting submitters, 29 submitters; last evaluated 2026-08-31). AlphaMissense: likely benign (0.1902); Ultra-rare (popmax 0.0604%, sas); Associated with hereditary neoplastic syndrome.

What condition is associated with BRIP1 p.Arg419Trp (c.1255C>T)?

BRIP1 p.Arg419Trp (c.1255C>T) is associated with hereditary neoplastic syndrome, hereditary breast ovarian cancer syndrome, breast carcinoma (ClinVar).

How common is BRIP1 p.Arg419Trp (c.1255C>T) in the general population?

BRIP1 p.Arg419Trp (c.1255C>T) is ultra-rare (popmax 0.0604%, sas) (gnomAD).

What do computational predictors say about BRIP1 p.Arg419Trp (c.1255C>T)?

AlphaMissense predicts likely benign (score 0.1902) — an in-silico prediction, not a clinical call.

BRIP1 p.Arg419Trp

c.1255C>T · rs150624408 · VCV128153

Conflicting classifications of pathogenicity Conflicting submitters

Classification

Conflicting classifications of pathogenicity

ClinVar

Review

Conflicting submitters ★☆☆☆

ClinVar · 29 submitters

AlphaMissense

likely benign

0.1902 · ACMG-weighted

gnomAD v4.1

Rare

ultra-rare (popmax 0.0604%, sas)

Missense predictors

1/2 damaging

AlphaMissense, SaProt · REVEL no call

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
AlphaMissense	0.1902	likely benign
REVEL	0.605	indeterminate
SaProt	LLR -11.13	damaging
⇒ SaProt calls this damaging; AlphaMissense does not; REVEL makes no call.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 5.7	GERP -0.32, phastCons 1
Regional constraint	o/e 0.92	unconstrained · MANE · 68 kb · p 0.065 · regional, not allelic
Overall
CADD	25.9	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.0604% South Asian · 55/91,054 alleles

Filtering AF 0.0476% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.043%

Overall 0.0268% 432/1,613,364 alleles · ultra-rare

Ancestry group	Frequency	1 in
South Asiangrpmax	0.0604%	1,656
European (non-Finnish)	0.0283%	3,532
Remaining individualsnot grpmax-eligible	0.024%	4,165
Ashkenazi Jewishnot grpmax-eligible	0.0237%	4,227
Finnishnot grpmax-eligible	0.0141%	7,114
Admixed American	0.01%	9,983
African / African-American	0.00668%	14,966
East Asian	0.00223%	44,878

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: BRIP1
Protein: p.Arg419Trp
Coding: c.1255C>T
MANE Select: NM_032043
dbSNP: rs150624408
Type: single nucleotide variant
Location: chr17:61799185 (GRCh38)
Gene constraint: LOEUF 0.848 · pLI <0.01 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 64.19 · 6 PDB
Residue 419: the helicase atp-binding domain; a UniProt-annotated variant site (in)

Full BRIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: hereditary breast ovarian cancer syndrome breast carcinoma breast cancer ovarian cancer Fanconi anemia complementation group J hereditary breast carcinoma

Similar variants

BRIP1 p.Arg419Gln Uncertain significance ★★ ⚠ same residue
BRIP1 p.Arg419Gly Uncertain significance ★★ ⚠ same residue
BRIP1 p.Arg419Pro Uncertain significance ★★ ⚠ same residue
BRIP1 p.Arg419= Conflicting classifications of pathogenicity ★ same residue
BRIP1 p.Arg419Leu Uncertain significance ★ ⚠ same residue
BRIP1 p.Arg419fs Pathogenic ★ same residue
BRIP1 c.1140+1G>A Likely pathogenic ★★ same condition
BRIP1 c.1141-2A>C Likely pathogenic ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/brip1-p-arg419trp (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown