Is CARD6 p.Arg651Ser (c.1953G>T) pathogenic?

CARD6 p.Arg651Ser (c.1953G>T) is classified Uncertain significance in CARD6 (ClinVar, Single submitter, 1 submitter; last evaluated 2025-02-13). AlphaMissense: likely pathogenic (0.6849); Very rare (popmax 0.00333%, amr).

How common is CARD6 p.Arg651Ser (c.1953G>T) in the general population?

CARD6 p.Arg651Ser (c.1953G>T) is very rare (popmax 0.00333%, amr) (gnomAD).

What do computational predictors say about CARD6 p.Arg651Ser (c.1953G>T)?

AlphaMissense predicts likely pathogenic (score 0.6849) — an in-silico prediction, not a clinical call.

CARD6 p.Arg651Ser

c.1953G>T · VCV3827395

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely pathogenic

0.6849 · ACMG-weighted

gnomAD v4.1

Rare

very rare (popmax 0.00333%, amr)

Missense predictors

1/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.6849	likely pathogenic · top 5% in CARD6
REVEL	0.26	benign-leaning
SaProt	LLR -9.75	tolerated
⇒ AlphaMissense calls this damaging; REVEL and SaProt do not.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 2.3	GERP -1.9, phastCons 1
Regional constraint	o/e 1.00	unconstrained · MANE · 13 kb · p 0.91 · regional, not allelic
Overall
CADD	23.4	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00333% Admixed American · 2/59,996 alleles

Filtering AF 0.000553% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.000207%

Overall 0.000186% 3/1,614,060 alleles · very rare

Ancestry group	Frequency	1 in
Admixed Americangrpmax	0.00333%	29,998
European (non-Finnish)	8.47e-05%	1,180,036

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: CARD6
Protein: p.Arg651Ser
Coding: c.1953G>T
MANE Select: NM_032587
Type: single nucleotide variant
Location: chr5:40853285 (GRCh38)
Gene constraint: LOEUF 1.487 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 55.25

Full CARD6 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

CARD6 p.Arg93Lys Benign ★★ same type
CARD6 p.Cys185Tyr Benign ★★ same type
CARD6 p.Gly264Glu Benign ★★ same type
CARD6 p.Ile194Val Benign ★★ same type
CARD6 p.Ala1022Asp Uncertain significance ★ ⚠ same type
CARD6 p.Ala110Thr Conflicting classifications of pathogenicity ★ ⚠ same type
CARD6 p.Ala159Thr Uncertain significance ★ ⚠ same type
CARD6 p.Ala340Thr Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/card6-p-arg651ser (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown