CARD6 — 159 ClinVar variants

All ClinVar germline CARD6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 140 flagged for review →

1 Conflicting · 4 Benign · 16 Likely benign · 138 Uncertain significance

Full CARD6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 140

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

CARD6 p.Ala110Thr Conflicting Single submitter

Predictors lean, ClinVar uncertain 89

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 50

The independent predictors disagree with each other — read with care.

All CARD6 variants

Conflicting classifications of pathogenicity 1

p.Ala110Thr Single submitter ⚠

Benign 4

p.Arg93Lys Multiple submitters
p.Cys185Tyr Multiple submitters
p.Gly264Glu Multiple submitters
p.Ile194Val Multiple submitters

Likely benign 16

p.Ala226Thr Single submitter
p.Ala648Ser Single submitter
p.Ala70Val Single submitter
p.Ala924Pro Single submitter
p.Arg807Gln Single submitter
p.Asp945Asn Single submitter
p.Cys559Tyr Single submitter
p.Gln708Glu Single submitter
p.His24Gln Single submitter
p.Ile344Val Single submitter
p.Ile702Val Single submitter
p.Ile849Val Single submitter
p.Leu160Trp Single submitter ⚠
p.Leu690Pro Single submitter
p.Lys164Glu Single submitter
p.Val239Ile Single submitter

Uncertain significance 138

p.Ala1022Asp Single submitter ⚠
p.Ala159Thr Single submitter ⚠
p.Ala340Thr Single submitter ⚠
p.Ala528Pro Single submitter ⚠
p.Ala528Val Single submitter ⚠
p.Ala587Thr Single submitter ⚠
p.Ala650Thr Single submitter ⚠
p.Ala698Thr Single submitter ⚠
p.Ala881Thr Single submitter ⚠
p.Arg297Lys Single submitter ⚠
p.Arg313Gln Single submitter ⚠
p.Arg313Gly Single submitter ⚠
p.Arg459Ser Single submitter ⚠
p.Arg498Trp Single submitter ⚠
p.Arg533Cys Single submitter ⚠
p.Arg533His Single submitter ⚠
p.Arg588Gly Single submitter ⚠
p.Arg58Gln Single submitter ⚠
p.Arg651Ser Single submitter ⚠
p.Arg755Cys Single submitter ⚠
p.Arg807Leu Single submitter ⚠
p.Arg820Gly Single submitter ⚠
p.Arg832Lys Single submitter ⚠
p.Arg841Ser Single submitter ⚠
p.Asp116Ala Single submitter ⚠
p.Asp196Asn Single submitter ⚠
p.Asp196Glu Single submitter ⚠
p.Asp324Asn Single submitter ⚠
p.Asp351Val Single submitter ⚠
p.Asp353Gly Single submitter ⚠
p.Asp357Asn Single submitter ⚠
p.Asp426Glu Single submitter ⚠
p.Asp515His Single submitter ⚠
p.Asp617His Single submitter ⚠
p.Cys315Arg Single submitter ⚠
p.Cys90Tyr Single submitter ⚠
p.Cys975Trp Single submitter ⚠
p.Gln1006His Single submitter ⚠
p.Gln1011Pro Single submitter ⚠
p.Gln489Arg Single submitter ⚠
p.Gln499Lys Single submitter ⚠
p.Gln713Arg Single submitter ⚠
p.Gln73Pro Single submitter ⚠
p.Gln870Pro Single submitter ⚠
p.Gln900Glu Single submitter ⚠
p.Gln906Arg Single submitter ⚠
p.Gln917Arg Single submitter ⚠
p.Gln981His Single submitter ⚠
p.Glu263Ala Single submitter ⚠
p.Glu272Ala Single submitter ⚠
p.Glu272Val Single submitter ⚠
p.Glu276Gln Single submitter ⚠
p.Glu363Lys Single submitter ⚠
p.Glu4Lys Single submitter ⚠
p.Glu652Gly Single submitter ⚠
p.Glu840Val Single submitter ⚠
p.Gly1034Glu Single submitter ⚠
p.Gly184Arg Single submitter ⚠
p.Gly197Arg Single submitter ⚠
p.Gly243Asp Single submitter ⚠
p.Gly264Val Single submitter ⚠
p.Gly922Ser Single submitter ⚠
p.Gly932Arg Single submitter ⚠
p.His1026Arg Single submitter ⚠
p.His139Arg Single submitter ⚠
p.His24Tyr Single submitter ⚠
p.His347Gln Single submitter ⚠
p.His488Tyr Single submitter ⚠
p.His851Arg Single submitter ⚠
p.His895Tyr Single submitter ⚠
p.Ile279Val Single submitter ⚠
p.Ile427Thr Single submitter ⚠
p.Ile702Thr Single submitter ⚠
p.Leu142Phe Single submitter ⚠
p.Leu18Phe Single submitter ⚠
p.Leu405Val Single submitter ⚠
p.Leu407Pro Single submitter ⚠
p.Leu567Met Single submitter ⚠
p.Leu568Pro Single submitter ⚠
p.Leu602Val Single submitter ⚠
p.Leu649Val Single submitter ⚠
p.Leu653Met Single submitter ⚠
p.Lys1013Asn Single submitter ⚠
p.Lys195Glu Single submitter ⚠
p.Lys316Gln Single submitter ⚠
p.Lys348Arg Single submitter ⚠
p.Lys355Arg Single submitter ⚠
p.Lys355Glu Single submitter ⚠
p.Lys425Glu Single submitter ⚠
p.Met108Ile Single submitter ⚠
p.Met753Ile Single submitter ⚠
p.Phe247Leu Single submitter ⚠
p.Phe522Leu Single submitter ⚠
p.Phe539Ser Single submitter ⚠
p.Phe543Ser Single submitter ⚠
p.Phe554Leu Single submitter ⚠
p.Phe724Ser Single submitter ⚠
p.Phe771Cys Single submitter ⚠
p.Phe799Leu Single submitter ⚠
p.Phe815Cys Single submitter ⚠
p.Pro1019Leu Single submitter ⚠
p.Pro104Ser Single submitter ⚠
p.Pro221Ala Single submitter ⚠
p.Pro439Leu Single submitter ⚠
p.Pro477Ala Single submitter ⚠
p.Pro477Leu Single submitter ⚠
p.Pro604Ala Single submitter ⚠
p.Pro830Ala Single submitter ⚠
p.Pro830Thr Single submitter ⚠
p.Pro894Leu Single submitter ⚠
p.Pro910Ser Single submitter ⚠
p.Pro910Thr Single submitter ⚠
p.Pro949Leu Single submitter ⚠
p.Pro984Ser Single submitter ⚠
p.Ser217Cys Single submitter ⚠
p.Ser468Ala Single submitter ⚠
p.Ser670Tyr Single submitter ⚠
p.Ser694Cys Single submitter ⚠
p.Ser712Arg Single submitter ⚠
p.Ser746Phe Single submitter ⚠
p.Ser944Cys Single submitter ⚠
p.Ser947Phe Single submitter ⚠
p.Ser950Phe Single submitter ⚠
p.Ser955Cys Single submitter ⚠
p.Thr32Met Single submitter ⚠
p.Thr382Ile Single submitter ⚠
p.Thr433Arg Single submitter ⚠
p.Thr440Ile Single submitter ⚠
p.Thr473Pro Single submitter ⚠
p.Thr508Pro Single submitter ⚠
p.Thr990Ala Single submitter ⚠
p.Trp867Arg Single submitter ⚠
p.Tyr233Cys Single submitter ⚠
p.Tyr462Cys Single submitter ⚠
p.Val239Ala Single submitter ⚠
p.Val657Ile Single submitter ⚠
p.Val752Ala Single submitter ⚠
p.Val963Met Single submitter ⚠