CCR10 p.Pro155=
c.465C>G · rs34866491 · VCV785571
Benign
Multiple submitters
Classification
Benign
ClinVar
Review
Multiple submitters ★★☆☆
ClinVar · 2 submitters
gnomAD v4.1
Rare
low-frequency (popmax 3.85%, afr)
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP -4.2 | GERP -5 |
| Overall | ||
| CADD | 1.185 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Grpmax group
3.85%
African / African-American · 2,885/74,964 alleles
Filtering AF
3.73%
ClinGen BA1/BS1 input
FAF95, joint · FAF99 3.68%
Overall
0.215%
3,468/1,610,730 alleles · low-frequency
| Ancestry group | Frequency | 1 in |
|---|---|---|
| African / African-Americangrpmax | 3.85% | 26 |
| Remaining individualsnot grpmax-eligible | 0.303% | 330 |
| Admixed American | 0.274% | 365 |
| Middle Eastern | 0.182% | 550 |
| European (non-Finnish) | 0.0176% | 5,696 |
| South Asian | 0.0132% | 7,567 |
Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.
Variant & gene context
- Gene
- CCR10
- Protein
- p.Pro155=
- Coding
- c.465C>G
- MANE Select
- NM_001296 · reported on NM_016602
- dbSNP
- rs34866491
- Type
- single nucleotide variant
- Location
- chr17:42680177 (GRCh38)
- Structure
- AlphaFold pLDDT 80.89 · 3 PDB
- Residue 155
- a disulfide bond
Similar variants
- CCR10 p.Leu267Met Uncertain significance ★★ ⚠ same type
- CCR9 p.Leu136= Benign ★★ same type
- ACKR2 p.Ala248Thr Uncertain significance ★ ⚠ same type
- ACKR2 p.Cys284Arg Uncertain significance ★ same type
- ACKR2 p.His317Tyr Uncertain significance ★ ⚠ same type
- ACKR2 p.Ile56Val Uncertain significance ★ ⚠ same type
- ACKR2 p.Leu59Trp Uncertain significance ★ ⚠ same type
- ACKR2 p.Ser172Cys Uncertain significance ★ ⚠ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/ccr10-p-pro155 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown