CCR10 — 44 ClinVar variants
All ClinVar germline CCR10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Benign · 2 Likely benign · 40 Uncertain significance
Full CCR10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCR10 p.Ala284Asp Uncertain significance Single submitter
- CCR10 p.Ala99Glu Uncertain significance Single submitter
- CCR10 p.Arg144Gln Uncertain significance Single submitter
- CCR10 p.Arg278Ser Uncertain significance Single submitter
- CCR10 p.Arg343Gln Uncertain significance Single submitter
- CCR10 p.Asn59Ser Uncertain significance Single submitter
- CCR10 p.Glu25Gly Uncertain significance Single submitter
- CCR10 p.Gly16Ala Uncertain significance Single submitter
- CCR10 p.Gly239Arg Uncertain significance Single submitter
- CCR10 p.Gly333Arg Uncertain significance Single submitter
- CCR10 p.Gly55Arg Uncertain significance Single submitter
- CCR10 p.Ile164Val Uncertain significance Single submitter
- CCR10 p.Leu81Val Uncertain significance Single submitter
- CCR10 p.Leu89Phe Uncertain significance Single submitter
- CCR10 p.Phe312Tyr Uncertain significance Single submitter
- CCR10 p.Pro26Leu Uncertain significance Single submitter
- CCR10 p.Pro352Ala Uncertain significance Single submitter
- CCR10 p.Ser23Leu Uncertain significance Single submitter
- CCR10 p.Thr233Met Uncertain significance Single submitter
- CCR10 p.Thr77Ile Uncertain significance Single submitter
- CCR10 p.Val140Leu Uncertain significance Single submitter
- CCR10 p.Val165Met Uncertain significance Single submitter
- CCR10 p.Val250Ala Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CCR10 p.Leu267Met Uncertain significance Multiple submitters
- CCR10 p.Ala143Thr Uncertain significance Single submitter
- CCR10 p.Ala301Val Uncertain significance Single submitter
- CCR10 p.Ala311Gly Uncertain significance Single submitter
- CCR10 p.Ala34Val Uncertain significance Single submitter
- CCR10 p.Ala99Thr Uncertain significance Single submitter
- CCR10 p.Arg316Ser Uncertain significance Single submitter
- CCR10 p.Arg326Gln Uncertain significance Single submitter
- CCR10 p.Glu279Lys Uncertain significance Single submitter
- CCR10 p.Gly149Trp Uncertain significance Single submitter
- CCR10 p.Leu49Val Uncertain significance Single submitter
- CCR10 p.Pro28Arg Uncertain significance Single submitter
- CCR10 p.Ser350Leu Uncertain significance Single submitter
- CCR10 p.Ser46Ile Uncertain significance Single submitter
- CCR10 p.Ser78Phe Uncertain significance Single submitter
- CCR10 p.Thr112Ile Uncertain significance Single submitter
- CCR10 p.Val51Met Uncertain significance Single submitter
All CCR10 variants
Likely benign 2
- p.Asp17Glu Single submitter
- p.Ser329Gly Single submitter
Uncertain significance 40
- p.Leu267Met Multiple submitters ⚠
- p.Ala143Thr Single submitter ⚠
- p.Ala284Asp Single submitter ⚠
- p.Ala301Val Single submitter ⚠
- p.Ala311Gly Single submitter ⚠
- p.Ala34Val Single submitter ⚠
- p.Ala99Glu Single submitter ⚠
- p.Ala99Thr Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg278Ser Single submitter ⚠
- p.Arg316Ser Single submitter ⚠
- p.Arg326Gln Single submitter ⚠
- p.Arg343Gln Single submitter ⚠
- p.Asn59Ser Single submitter ⚠
- p.Glu25Gly Single submitter ⚠
- p.Glu279Lys Single submitter ⚠
- p.Gly149Trp Single submitter ⚠
- p.Gly16Ala Single submitter ⚠
- p.Gly239Arg Single submitter ⚠
- p.Gly333Arg Single submitter ⚠
- p.Gly55Arg Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Leu49Val Single submitter ⚠
- p.Leu81Val Single submitter ⚠
- p.Leu89Phe Single submitter ⚠
- p.Phe312Tyr Single submitter ⚠
- p.Pro26Leu Single submitter ⚠
- p.Pro28Arg Single submitter ⚠
- p.Pro352Ala Single submitter ⚠
- p.Ser23Leu Single submitter ⚠
- p.Ser350Leu Single submitter ⚠
- p.Ser46Ile Single submitter ⚠
- p.Ser78Phe Single submitter ⚠
- p.Thr112Ile Single submitter ⚠
- p.Thr233Met Single submitter ⚠
- p.Thr77Ile Single submitter ⚠
- p.Val140Leu Single submitter ⚠
- p.Val165Met Single submitter ⚠
- p.Val250Ala Single submitter ⚠
- p.Val51Met Single submitter ⚠