CD151 p.Gly176fs
c.527_533del · VCV4976588
Uncertain significance
Single submitter
Classification
Uncertain significance
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
Consequence
frameshift
predicted LoF
gnomAD v4.1
Rare
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Consequence | frameshift | predicted loss-of-function |
|---|---|---|
| NMD | predicted | premature termination codon in exon 7 of 9 |
| Splicing | ||
| SpliceAI | — | not assessed · substitutions only |
| Constraint at this position | ||
| Conservation | phyloP 2.5 | GERP 0.54, phastCons 0.9 |
Predicted loss-of-function is descriptive, not an applied PVS1 code.
Variant & gene context
- Gene
- CD151
- Protein
- p.Gly176fs
- Coding
- c.527_533del
- MANE Select
- NM_004357
- Type
- Deletion
- Location
- chr11:837525 (GRCh38)
- Gene constraint
- LOEUF 0.816 · pLI <0.01 (gnomAD)
- Structure
- AlphaFold pLDDT 88.02
Similar variants
- CD151 p.Gly176Ser Uncertain significance ★ ⚠ same residue
- CD151 p.Cys208_Thr210del Likely pathogenic ★ same type
- CD151 c.616-42_616-11del Uncertain significance ★ same type
- CD151 p.Thr10del Uncertain significance ★ same type
- CD151 c.276+107del Benign ★ same type
- CD151 c.277-3del Benign ★ same type
- CD151 c.615+44del Benign ★ same type
- CD151 c.615+51del Benign ★ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/cd151-p-gly176fs (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown